HucMSC extracellular vesicles increasing SATB 1 to activate the Wnt/β-catenin pathway in 6-OHDA-induced Parkinson's disease model.

Publisher: Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis Country of Publication: England NLM ID: 100888706 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-6551 (Electronic) Linking ISSN: 15216543 NLM ISO Abbreviation: IUBMB Life Subsets: MEDLINE

Original Publication: London ; Philadelphia, PA : Published for the International Union of Biochemistry and Molecular Biology by Taylor & Francis, c1999-

Oxidopamine* ; Wnt Signaling Pathway* ; Extracellular Vesicles*/metabolism ; Extracellular Vesicles*/transplantation ; Mesenchymal Stem Cells*/metabolism ; Matrix Attachment Region Binding Proteins*/metabolism ; Matrix Attachment Region Binding Proteins*/genetics; Animals ; Humans ; Mice ; Disease Models, Animal ; Parkinson Disease/metabolism ; Parkinson Disease/pathology ; Parkinson Disease/therapy ; beta Catenin/metabolism ; beta Catenin/genetics ; Umbilical Cord/cytology ; Autophagy ; Male ; Dopaminergic Neurons/metabolism ; Dopaminergic Neurons/pathology ; Mice, Inbred C57BL

Parkinson's disease (PD) is a degenerative disorder of the nervous system characterized by the loss of dopaminergic neurons and damage of neurons in the substantia nigra (SN) and striatum, resulting in impaired motor functions. This study aims to investigate how extracellular vesicles (EVs) derived from human umbilical cord mesenchymal stem cells (HucMSC) regulate Special AT-rich sequence-binding protein-1 (SATB 1) and influence Wnt/β-catenin pathway and autophagy in PD model. The PD model was induced by damaging SH-SY5Y cells and mice using 6-OHDA. According to the study, administering EVs every other day for 14 days improved the motor behavior of 6-OHDA-induced PD mice and reduced neuronal damage, including dopaminergic neurons. Treatment with EVs for 12 hours increased the viability of 6-OHDA-induced SH-SY5Y cells. The upregulation of SATB 1 expression with EV treatment resulted in the activation of the Wnt/β-catenin pathway in PD model and led to overexpression of β-catenin. Meanwhile, the expression of LC3 II was decreased, indicating alterations in autophagy. In conclusion, EVs could mitigate neuronal damage in the 6-OHDA-induced PD model by upregulating SATB 1 and activating Wnt/β-catenin pathway while also regulating autophagy. Further studies on the potential therapeutic applications of EVs for PD could offer new insights and strategies.
(© 2024 International Union of Biochemistry and Molecular Biology.)

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2023GXNSFAA026137 Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation; Z20170932 Guangxi Zhuang Autonomous Region Health and Family Planning Commission; 2018YFA0108304 National Natural Science Foundation of China; Z20190247 Foundation of Self-funded Scientific Research Subject of Guangxi Zhuang Autonomous Region Health Commission

Keywords: Parkinson's disease; SATB 1; Wnt/β‐catenin; autophagy; extracellular vesicles

8HW4YBZ748 (Oxidopamine)
0 (Matrix Attachment Region Binding Proteins)
0 (beta Catenin)

Date Created: 20240731 Date Completed: 20241121 Latest Revision: 20241121

20241121

10.1002/iub.2893

39082886