Bone lesions and intestinal barrier disruption caused by the isolated novel goose parvovirus infection in ducks.

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  • Additional Information
    • Source:
      Publisher: Academic Press Country of Publication: England NLM ID: 8606191 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-1208 (Electronic) Linking ISSN: 08824010 NLM ISO Abbreviation: Microb Pathog Subsets: MEDLINE
    • Publication Information:
      Original Publication: London ; Orlando : Academic Press, c1986-
    • Subject Terms:
      Ducks*/virology ; Parvoviridae Infections*/veterinary ; Parvoviridae Infections*/virology ; Parvoviridae Infections*/pathology ; Poultry Diseases*/virology ; Poultry Diseases*/pathology ; Phylogeny*; Animals ; China ; Parvovirinae/genetics ; Parvovirinae/isolation & purification ; Parvovirinae/pathogenicity ; Gastrointestinal Microbiome ; Intestines/pathology ; Intestines/virology ; RNA, Ribosomal, 16S/genetics ; Disease Models, Animal ; Dysbiosis/virology ; Dysbiosis/veterinary ; Fatty Acids, Volatile/metabolism ; Geese/virology ; Spleen/pathology ; Spleen/virology ; Beak/virology ; Beak/pathology
    • Abstract:
      Short beak and dwarfism syndrome (SBDS) is attributed to Novel Goose Parvovirus (NGPV), which has inflicted significant economic losses on farming in China. Despite its significant impact, limited research has been conducted on the pathogenesis of this disease. The SD strain, a parvovirus variant isolated from ducks in Shandong province, was identified and characterized in our study. Phylogenetic analysis and sequence comparisons confirmed the classification of the SD strain as a member of NGPV. Based on this information, we established an animal model of SBDS by inoculating Cherry Valley ducks with the SD strain. Our findings indicate that infection with the SD strain leads to a reduction in body weight, beak length, width, and tibia length. Notably, significant histopathological alterations were observed in the thymus, spleen, and intestine of the infected ducks. Furthermore, the SD strain induces bone disorders and inflammatory responses. To evaluate the impact of NGPV on intestinal homeostasis, we performed 16S rDNA sequencing and gas chromatography to analyze the composition of intestinal flora and levels of short-chain fatty acids (SCFAs) in the cecal contents. Our findings revealed that SD strain infection induces dysbiosis in cecal microbial and a decrease in SCFAs production. Subsequent analysis revealed a significant correlation between bacterial genera and the clinical symptoms in NGPV SD infected ducks. Our research providing novel insights into clinical pathology of NGPV in ducks and providing a foundation for the research of NGPV treatment targeting gut microbiota.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024. Published by Elsevier Ltd.)
    • Contributed Indexing:
      Keywords: Bone loss; Gut microbiota; Intestinal damage; Novel goose parvovirus (NGPV); Short beak and dwarfism syndrome (SBDS)
    • Accession Number:
      0 (RNA, Ribosomal, 16S)
      0 (Fatty Acids, Volatile)
    • Subject Terms:
      Avian dependoparvovirus 1
    • Publication Date:
      Date Created: 20240729 Date Completed: 20240831 Latest Revision: 20240831
    • Publication Date:
      20240902
    • Accession Number:
      10.1016/j.micpath.2024.106825
    • Accession Number:
      39074517