Impact of Bisphenol A exposure on maternal gut microbial homeostasis, placental function, and fetal development during pregnancy.

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  • Additional Information
    • Source:
      Publisher: Pergamon In Cooperation With The Reproductive Toxicology Center Country of Publication: United States NLM ID: 8803591 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1708 (Electronic) Linking ISSN: 08906238 NLM ISO Abbreviation: Reprod Toxicol Subsets: MEDLINE
    • Publication Information:
      Publication: Elmsford Ny : Pergamon In Cooperation With The Reproductive Toxicology Center
      Original Publication: Elmsford, N.Y., U.S.A. : Pergamon Press, c1987-
    • Subject Terms:
      Benzhydryl Compounds*/toxicity ; Phenols*/toxicity ; Placenta*/drug effects ; Placenta*/microbiology ; Gastrointestinal Microbiome*/drug effects ; Fetal Development*/drug effects ; Endocrine Disruptors*/toxicity ; Homeostasis*/drug effects; Female ; Pregnancy ; Humans ; Animals ; Maternal Exposure/adverse effects ; Maternal-Fetal Exchange ; Environmental Pollutants/toxicity
    • Abstract:
      Pregnancy is extremely vulnerable to external environmental influences. Bisphenol A, an endocrine-disrupting chemical, poses a significant environmental hazard to individuals of all ages and stages, particularly during pregnancy. The placenta is a temporary organ facilitating the connection between the mother and fetus. While it can detoxify certain exogenous substances, it is also vulnerable to the impacts of endocrine disruptors. Likewise, the intestinal flora is highly sensitive to exogenous stresses and environmental pollutants. The regulation of gut microbiota plays a crucial role in ensuring the health of both the mother and the fetus. The gut-placental axis connects the gut, gut microbes, placenta, and fetus. Exploring possible effects on placental function and fetal development involves analyzing changes in gut microbiota composition. Given that bisphenol A may cross the intestine and affect intestinal function, gut microorganisms, and their metabolites, as well as its potential impact on the placenta, resulting in impaired placental function and fetal development, this study aims to establish a link between bisphenol A exposure, intestinal microorganisms, placental function, and fetal development. This paper seeks to analyze the effects of maternal exposure to bisphenol A during pregnancy on the balance of the maternal gut microbiota, placental function, and fetal development, considering the key role of the gut-placental axis. Additionally, this paper proposes potential directions for future research emphasizing the importance of mitigating the adverse outcomes of bisphenol A exposure during pregnancy in both human and animal studies.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bisphenol A; Fetal development; Gut microbiota; Gut-placental axis; Placenta; Pregnancy
    • Accession Number:
      0 (Benzhydryl Compounds)
      MLT3645I99 (bisphenol A)
      0 (Phenols)
      0 (Endocrine Disruptors)
      0 (Environmental Pollutants)
    • Publication Date:
      Date Created: 20240727 Date Completed: 20240905 Latest Revision: 20240926
    • Publication Date:
      20240926
    • Accession Number:
      10.1016/j.reprotox.2024.108677
    • Accession Number:
      39067774