Pressure fermentation to boost CO 2 -based poly(3-hydroxybutyrate) production using Cupriavidus necator.

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  • Additional Information
    • Source:
      Publisher: Elsevier Applied Science Country of Publication: England NLM ID: 9889523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2976 (Electronic) Linking ISSN: 09608524 NLM ISO Abbreviation: Bioresour Technol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Barking, Essex, England : New York, N.Y. : Elsevier Applied Science ; Elsevier Science Pub. Co., 1991-
    • Subject Terms:
      Cupriavidus necator*/metabolism ; Hydroxybutyrates*/metabolism ; Polyesters*/metabolism ; Fermentation* ; Carbon Dioxide*/metabolism ; Pressure* ; Bioreactors*; Oxygen/metabolism ; Polyhydroxybutyrates
    • Abstract:
      CO 2 -based poly(3-hydroxybutyrate) (PHB) can be produced by the versatile bacterium Cupriavidus necator through chemolithoautotrophic fermentation, using a gas mixture consisting of CO 2 , H 2 , and O 2 . Despite offering a propitious route for carbon-neutral bioplastic manufacturing, its adoption is currently hampered by the wide explosive range of the required gas mixture, as well as the limited gas-to-liquid mass transfer rates. To address these challenges, pressure fermentation was applied as a robust and effective strategy, while ensuring safe operation by adhering to the limiting O 2 concentration, utilizing state-of-the-art bioreactors. Consequently, exponential growth could be prolonged, boosting CO 2 -based PHB production from 10.8 g/L at 1.5 bar up to 29.6 g/L at 3 bar. The production gain closely aligns with the theoretical calculations, except for when the pressure was increased up to 4 bar. Overall, the demonstrated increase in PHB production underscores the potential of pressure fermentation to enhance aerobic gas fermentation.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024. Published by Elsevier Ltd.)
    • Contributed Indexing:
      Keywords: Bioplastic; Bioreactor; Carbon capture and utilization (CCU); Gas fermentation; Pressure
    • Accession Number:
      0 (Hydroxybutyrates)
      0 (Polyesters)
      142M471B3J (Carbon Dioxide)
      26063-00-3 (poly-beta-hydroxybutyrate)
      S88TT14065 (Oxygen)
      0 (Polyhydroxybutyrates)
    • Publication Date:
      Date Created: 20240727 Date Completed: 20240818 Latest Revision: 20240818
    • Publication Date:
      20240819
    • Accession Number:
      10.1016/j.biortech.2024.131162
    • Accession Number:
      39067712