Functional architecture of intracellular oscillations in hippocampal dendrites.

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  • Additional Information
    • Source:
      Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : Nature Pub. Group
    • Subject Terms:
      Dendrites*/physiology ; Dendrites*/metabolism ; Pyramidal Cells*/physiology ; Pyramidal Cells*/metabolism ; CA1 Region, Hippocampal*/physiology ; CA1 Region, Hippocampal*/cytology; Animals ; Mice ; Membrane Potentials/physiology ; Male ; Mice, Inbred C57BL ; Hippocampus/physiology ; Hippocampus/cytology ; Spatial Navigation/physiology ; Locomotion/physiology
    • Abstract:
      Fast electrical signaling in dendrites is central to neural computations that support adaptive behaviors. Conventional techniques lack temporal and spatial resolution and the ability to track underlying membrane potential dynamics present across the complex three-dimensional dendritic arbor in vivo. Here, we perform fast two-photon imaging of dendritic and somatic membrane potential dynamics in single pyramidal cells in the CA1 region of the mouse hippocampus during awake behavior. We study the dynamics of subthreshold membrane potential and suprathreshold dendritic events throughout the dendritic arbor in vivo by combining voltage imaging with simultaneous local field potential recording, post hoc morphological reconstruction, and a spatial navigation task. We systematically quantify the modulation of local event rates by locomotion in distinct dendritic regions, report an advancing gradient of dendritic theta phase along the basal-tuft axis, and describe a predominant hyperpolarization of the dendritic arbor during sharp-wave ripples. Finally, we find that spatial tuning of dendritic representations dynamically reorganizes following place field formation. Our data reveal how the organization of electrical signaling in dendrites maps onto the anatomy of the dendritic tree across behavior, oscillatory network, and functional cell states.
      (© 2024. The Author(s).)
    • Comments:
      Update of: bioRxiv. 2024 Feb 12:2024.02.12.579750. doi: 10.1101/2024.02.12.579750. (PMID: 38405778)
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    • Grant Information:
      R01 MH124047 United States MH NIMH NIH HHS; R01 MH124867 United States MH NIMH NIH HHS; RF1 NS133381 United States NS NINDS NIH HHS; T32 GM007367 United States GM NIGMS NIH HHS; T32 MH020016 United States MH NIMH NIH HHS; U01 NS103464 United States NS NINDS NIH HHS; R01NS121106 U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS); U01NS115530 U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS); R01MH124047 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); F31 NS120783 United States NS NINDS NIH HHS; R01 NS131728 United States NS NINDS NIH HHS; R01MH124867 U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH); RF1 AG080818 United States AG NIA NIH HHS; U01 NS115530 United States NS NINDS NIH HHS; RF1 MH114105 United States MH NIMH NIH HHS; R01 NS121106 United States NS NINDS NIH HHS; R01NS133381 U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS)
    • Publication Date:
      Date Created: 20240726 Date Completed: 20240728 Latest Revision: 20240730
    • Publication Date:
      20240730
    • Accession Number:
      PMC11282248
    • Accession Number:
      10.1038/s41467-024-50546-z
    • Accession Number:
      39060234