Terpenoids from the rhizomes of Curcuma kwangsiensis S.G. Lee et C.F. Ling and their anti-inflammatory activities.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 16930290R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6971 (Electronic) Linking ISSN: 0367326X NLM ISO Abbreviation: Fitoterapia Subsets: MEDLINE
    • Publication Information:
      Publication: 1999- : [Amsterdam] : Elsevier
      Original Publication: Milano : Inverni & Della Beffa S.p.A.
    • Subject Terms:
      Curcuma*/chemistry ; Rhizome*/chemistry ; Anti-Inflammatory Agents*/pharmacology ; Anti-Inflammatory Agents*/isolation & purification ; Anti-Inflammatory Agents*/chemistry ; Terpenes*/pharmacology ; Terpenes*/isolation & purification ; Terpenes*/chemistry; Animals ; Mice ; RAW 264.7 Cells ; Molecular Structure ; Nitric Oxide/metabolism ; Sesquiterpenes/pharmacology ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/chemistry ; Phytochemicals/pharmacology ; Phytochemicals/isolation & purification ; Macrophages/drug effects
    • Abstract:
      Three new sesquiterpenes, 4S-1-(3-hydroxybutyl)-7-(11-hydroxypropyl)-10-methyl- cyclohepta-7,5,10-trien-8-one (1), 8R-hydroxy-7-(4S-4,10-dimethyl-5-oxooct-1-en-7-yl)-11- methylfuran-12-one (2), (1S,5R,7S,10R)-1-hydroxy-7-(11-hydroxypropyl)-10-methyl-4- methyleneoctahydronaphthalen-8-one (3), along with 30 known terpenoids (4-33) were obtained from the rhizomes of Curcuma kwangsiensis S.G. Lee et C.F. Ling. Through comprehensive analysis of chemical evidence and spectral data including UV, ECD, IR, 1D and 2D NMR and HR-ESI-MS, as well as quantum chemical calculation, the structures of these novel compounds were successfully determined. Additionally, the inhibitory effects of compounds 1-2, 4-33 on NO production were evaluated in lipopolysaccharide (LPS)-induced RAW264.7 cells. Notably, compound 33 exhibited the most significant inhibitory effect with an IC 50 value of 3.55 ± 0.55 μM.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Anti-inflammatory activity; Curcuma kwangsiensis S. G. Lee et C. F. Liang; Terpenoids
    • Accession Number:
      0 (Anti-Inflammatory Agents)
      0 (Terpenes)
      31C4KY9ESH (Nitric Oxide)
      0 (Sesquiterpenes)
      0 (Phytochemicals)
    • Publication Date:
      Date Created: 20240725 Date Completed: 20240918 Latest Revision: 20240918
    • Publication Date:
      20240919
    • Accession Number:
      10.1016/j.fitote.2024.106137
    • Accession Number:
      39053742