Antitumor progestins activity: Cytostatic effect and immune response.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 0404536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5867 (Electronic) Linking ISSN: 0039128X NLM ISO Abbreviation: Steroids Subsets: MEDLINE
    • Publication Information:
      Publication: New York Ny : Elsevier
      Original Publication: San Francisco.
    • Subject Terms:
      Progestins*/pharmacology ; Progestins*/therapeutic use; Humans ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Cytostatic Agents/pharmacology
    • Abstract:
      Progestins are used to treat some hormone-sensitive tumors. This review discusses the mechanisms of progestins' effects on tumor cells, the differences in the effects of progesterone and its analogs on different tumor types, and the influence of progestins on the antitumor immune response. Progestins cause a cytostatic effect, but at the same time they can suppress the antitumor immune response, and this can promote the proliferation and metastasis of tumor cells. Such progestins as dienogest, megestrol acetate and levonorgestrel increase the activity of NK-cells, which play a major role in the body's fight against tumor cells. The use of existing progestins and the development of new drugs with gestagenic activity may hold promise in oncotherapy.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Antitumor activity; Immune responce; Neoplasms; Progestin receptor; Progestins
    • Accession Number:
      0 (Progestins)
      0 (Antineoplastic Agents)
      0 (Cytostatic Agents)
    • Publication Date:
      Date Created: 20240724 Date Completed: 20240816 Latest Revision: 20240819
    • Publication Date:
      20240819
    • Accession Number:
      10.1016/j.steroids.2024.109474
    • Accession Number:
      39048056