Surface modification of PVDF ultrafiltration membranes using spacer arms and synthetic receptors for virus capturing and separation.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2984816R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3573 (Electronic) Linking ISSN: 00399140 NLM ISO Abbreviation: Talanta Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Oxford : Pergamon Press
    • Subject Terms:
      Polyvinyls*/chemistry ; Membranes, Artificial* ; Ultrafiltration*/methods ; Surface Properties*; Hydrophobic and Hydrophilic Interactions ; Viruses/isolation & purification ; Molecular Imprinting/methods ; Polyethyleneimine/chemistry ; Water Purification/methods ; Nanoparticles/chemistry ; Fluorocarbon Polymers
    • Abstract:
      Although membrane technology has demonstrated outstanding pathogen removal capabilities, current commercial membranes are insufficient for removing small viruses at trace levels due to certain limitations. The theoretical and practical significance of developing a new form of hydrophilic, anti-fouling, and virus-specific ultra-purification membrane with high capturing and separation efficiency, stability, and throughput for water treatment is of the utmost importance. In this study, molecularly imprinted membranes (MIMs) were fabricated from polyvinylidene fluoride (PVDF) membranes utilizing novel surface hydrophilic modification techniques, followed by the immobilization of virus-specific molecularly imprinted nanoparticles (nanoMIPs) as synthetic receptors. Three distinct membrane functionalization strategies were established and optimized for the first time: membrane functionalization with (i) polyethyleneimine (PEI) and dopamine (DOP), (ii) PEI and 3-(chloropropyl)-trimethoxysilane (CTS), and (iii) chitosan (CS). Hydrophilicity was enhanced significantly as a result of these modification strategies. Additionally, the modifications enabled spacer arms between the membrane surface and the nanoMIPs to decrease steric hindrance. The surface chemistry, morphology, and membrane performance results from the characterization analysis of the MIMs demonstrated excellent hydrophilicity (e.g., the functionalized membrane presented 37.84° while the unmodified bare membrane exhibited 128.94° of water contact angle), higher permeation flux (145.96 L m -2  h -1 for the functionalized membrane), excellent uptake capacity (up to 99.99 % for PEI-DOP-MIM and CS-MIM), and recovery (more than 80 % for PEI-DOP-MIM). As proof of concept, the cutting-edge MIMs were able to eliminate the model adenoviruses up to 99.99 % from water. The findings indicate that the novel functionalized PVDF membranes hold promise for implementation in practical applications for virus capture and separation.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Adenoviruses; Hydrophilic functionalization; NanoMIP-based receptors; PVDF membrane; Surface modifications using spacer arms
    • Accession Number:
      24937-79-9 (polyvinylidene fluoride)
      0 (Polyvinyls)
      0 (Membranes, Artificial)
      9002-98-6 (Polyethyleneimine)
      0 (Fluorocarbon Polymers)
    • Publication Date:
      Date Created: 20240724 Date Completed: 20240830 Latest Revision: 20240830
    • Publication Date:
      20240830
    • Accession Number:
      10.1016/j.talanta.2024.126558
    • Accession Number:
      39047630