Blood Micro-sampling: An alternative blood collection method for radioiodine therapy dosimetry.

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  • Author(s): Al Jabri A;Al Jabri A;Al Jabri A; Cooke J; Cooke J; Cournane S; Cournane S; Healy ML; Healy ML
  • Source:
    Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [Phys Med] 2024 Aug; Vol. 124, pp. 103430. Date of Electronic Publication: 2024 Jul 23.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Istituti Editoriali e Poligrafici Internazionali Country of Publication: Italy NLM ID: 9302888 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1724-191X (Electronic) Linking ISSN: 11201797 NLM ISO Abbreviation: Phys Med Subsets: MEDLINE
    • Publication Information:
      Publication: Pisa : Istituti Editoriali e Poligrafici Internazionali
      Original Publication: Lugano, Switzerland : Giardini editori S.A.,
    • Subject Terms:
      Iodine Radioisotopes*/therapeutic use ; Blood Specimen Collection*/methods ; Radiometry*/methods; Humans ; Thyroid Neoplasms/radiotherapy ; Thyroid Neoplasms/blood ; Female
    • Abstract:
      Purpose: Collecting venous blood samples from patients post administration of high therapeutic activities results in radiation exposure to staff collecting the blood. This study investigated the use of finger-tip capillary-blood collection as an alternative to the venous-blood collection method recommended by the European Association of Nuclear Medicine (EANM) dosimetry protocol for quantifying 131 I concentration in the critical organ after therapeutic dose of 131 I.
      Methods: The study included differentiated thyroid cancer patients referred to a thyroid cancer centre at St James's Hospital, Ireland, for therapeutic and diagnostic oral administration of 131 I. The 15 patients recruited for this study provided 30 venous and capillary paired-blood samples. The activity concentration of the blood samples was compared between the type of blood (venous vs capillary) and the geometry/volume of the blood (1.0 ml versus 0.03 ml). Other variables were also investigated including administered activities, dose to staff performing the sampling, duration of sampling and time since administration.
      Results: Blood samples were taken at 2.0-91.9 h post administration using 0.2 ± 0.0 GBq (n = 2) or 4.0 ± 0.1 GBq (n = 28) 131 I activities. There was no significant difference found between different blood sampling types (-1.0 ± 4.3 %, p = 0.223), different blood volumes (-3.2 ± 10.0 %, p = 0.070), or between their combination. No significant correlation was found between the percentage differences and investigated parameters.
      Conclusion: A high degree of accuracy was achieved with blood radioactivity quantified using capillary blood collection using the finger-prick method. Further validation of the method would be required prior to implementation, to investigate patient specific factors which may affect accuracy.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: Dosimetry; Finger prick; I-131; Radioiodine; Thyroid; Venous blood
    • Accession Number:
      0 (Iodine Radioisotopes)
      0 (Iodine-131)
    • Publication Date:
      Date Created: 20240724 Date Completed: 20240809 Latest Revision: 20240809
    • Publication Date:
      20240812
    • Accession Number:
      10.1016/j.ejmp.2024.103430
    • Accession Number:
      39047405