Biomimetic Porous MXene Antibacterial Adsorbents with Enhanced Toxins Trapping Ability for Hemoperfusion.

Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE

Original Publication: Weinheim, Germany : Wiley-VCH, c2005-

Hemoperfusion*/methods ; Anti-Bacterial Agents*/chemistry ; Anti-Bacterial Agents*/pharmacology; Porosity ; Adsorption ; Titanium/chemistry ; Biomimetics/methods ; Biomimetic Materials/chemistry

2D transition metal carbides and nitrides, i.e., MXene, are recently attracting wide attentions and presenting competitive performances as adsorbents used in hemoperfusion. Nonetheless, the nonporous texture and easily restacking feature limit the efficient adsorption of toxin molecules inside MXene and between layers. To circumvent this concern, here a plerogyra sinuosa biomimetic porous titanium carbide MXene (P-Ti 3 C 2 ) is reported. The hollow and hierarchically porous structure with large surface area benefits the maximum access of toxins as well as trapping them inside the spherical cavity. The cambered surface of P-Ti 3 C 2 prevents layers restacking, thus affording better interlaminar adsorption. In addition to enhanced toxin removal ability, the P-Ti 3 C 2 is found to selectively adsorb more middle and large toxin molecules than small toxin molecules. It possibly originates from the rich Ti-deficient vacancies in the P-MXene lattice that increases the affinity with middle/large toxin molecules. Also, the vacancies as active sites facilitate the production of reactive oxygen under NIR irradiation to promote the photodynamic antibacterial performance. Then, the versatility of P-MXene is validated by extension to niobium carbide (P-Nb 2 C). And the simulated hemoperfusion proves the practicability of the P-MXene as polymeric adhesives-free adsorbents to eliminate the broad-spectrum toxins.
(© 2024 Wiley‐VCH GmbH.)

X. Song, H. Ji, Y. Li, Y. Xiong, L. Qiu, R. Zhong, M. Tian, J. N. Kizhakkedathu, B. Su, Q. Wei, W. Zhao, C. Zhao, Nat. Biomed. Eng. 2021, 5, 1143.
C. Ronco, R. Bellomo, Crit. Care. 2022, 26, 135.
M. Ghannoum, J. Bouchard, T. D. Nolin, G. Ouellet, D. M. Roberts, Semin. Dial. 2014, 27, 350.
Z. Ricci, S. Romagnoli, T. Reis, R. Bellomo, C. Ronco, Intensive Care Med. 2022, 48, 1397.
S. Wu, P. Yue, Y. Ma, Y. Zou, W. Liang, Q. Ye, Adv. Mater. 2023, 2305152.
W. Dou, J. Wang, Z. Yao, W. Xiao, M. Huang, L. Zhang, Mater. Adv. 2022, 3, 918.
L. Wang, K. Han, X. Jiang, C. Mao, X. Li, M. Zhou, Sustain. Mater. Technol. 2024, 39, e00828.
T. Kameda, K. Horikoshi, S. Kumagai, Y. Saito, T. Yoshioka, Sep. Purif. Technol. 2020, 237, 116367.
Y. Liu, Z.‐K. Wang, C.‐Z. Liu, Y.‐Y. Liu, Q. Li, H. Wang, F. Cui, D.‐W. Zhang, Z.‐T. Li, ACS Appl. Mater. Interfaces. 2022, 14, 47397.
C. Ye, Q. Gong, F. Lu, J. Liang, Sep. Purif. Technol. 2007, 58, 2.
J. Bai, Y. Huang, Q. Gong, X. Liu, Y. Li, J. Gan, M. Zhao, Y. Shao, D. Zhuang, J. Liang, Carbon. 2018, 137, 493.
F. Yang, P. Yang, Macromol. Rapid Commun. 2021, 43, 22100669.
F. Yang, F. Tao, C. Li, L. Gao, P. Yang, Nat. Commun. 2018, 9, 5443.
Y. Wang, S. Wang, X. He, Y. Li, T. Xu, L. Xu, B. Yang, X. Fan, W. Zhao, C. Zhao, Bioact. Mater. 2023, 20, 651.
S. Daneshamouz, U. Eduok, A. Abdelrasoul, A. Shoker, NanoImpact. 2021, 21, 100299.
H. Yue, L. Yuan, W. Zhang, S. Zhang, W. Wei, G. Ma, J. Mater. Chem. B. 2018, 6, 393.
Y. Yang, S. Yin, C. He, X. Wu, J. Yin, J. Zhang, L. Ma, W. Zhao, C. Cheng, C. Zhao, J. Mater. Chem. B. 2020, 8, 1960.
R. Weng, L. Zhang, Y. Cao, Z. Wang, C. Zhao, J. Wang, C. Zhao, Chem. Eng. J. 2023, 463, 142365.
H. Zhao, J. Huang, L. Miao, Y. Yang, Z. Xiao, Q. Chen, Q. Huang, K. Ai, Chem. Eng. J. 2022, 438, 135583.
F. Meng, M. Seredych, C. Chen, V. Gura, S. Mikhalovsky, S. Sandeman, G. Ingavle, T. Ozulumba, L. Miao, B. Anasori, Y. Gogotsi, ACS Nano. 2018, 12, 10518.
Q. Zhao, M. Seredych, E. Precetti, C. E. Shuck, M. Harhay, R. Pang, C.‐X. Shan, Y. Gogotsi, ACS Nano. 2020, 14, 11787.
T. Wang, X. Sun, X. Guo, J. Zhang, J. Yang, S. Tao, J. Guan, L. Zhou, J. Han, C. Wang, H. Yao, G. Wang, Small Methods. 2021, 5, 2001108.
T. Wang, W. Gu, L. Yu, X. Guo, J. Yang, X. Sun, J. Guan, L. Zhou, C. Wang, H. Yao, X. Zhang, G. Wang, J. Materiomics. 2023, 9, 1129.
X. Sun, J. Yang, D. Su, C. Wang, G. Wang, Chem. Asian J. 2021, 16, 1949.
H. Wei, X. Li, C. Li, K. Wang, Z. Liu, J. Lu, B. Liu, X. He, Chemosphere. 2023, 337, 139303.
M. Zhao, X. Xie, C. E. Ren, T. Makaryan, B. Anasori, G. Wang, Y. Gogotsi, Adv. Mater. 2017, 29, 1702410.
K. Lv, J. Zhang, X. Zhao, N. Kong, J. Tao, J. Zhou, Small. 2022, 18, 2202203.
F. Pan, Y. Shi, Y. Yang, H. Guo, L. Li, H. Jiang, X. Wang, Z. Zeng, W. Lu, Adv. Mater. 2024, 36, 2311135.
X. Ye, C. Yang, L. Wang, Q. Fan, L. Shang, F. Ye, Aggregate. 2024, e542.
G. Zhang, D. Shao, H. Yu, Y. Wan, Y. Jiao, L. Li, J. Tian, C. Zhou, L. Lu, ACS Appl. Nano Mater. 2022, 5, 17293.
K. Li, X. Wang, S. Li, P. Urbankowski, J. Li, Y. Xu, Y. Gogotsi, Small. 2020, 16, 1906851.
Y. Zhu, K. Rajouâ, S. Le Vot, O. Fontaine, P. Simon, F. Favier, Nano Energy. 2020, 73, 104734.
X. Chang, Q. Zhu, Q. Zhao, P. Zhang, N. Sun, R. A. Soomro, X. Wang, B. Xu, ACS Appl. Mater. Interfaces. 2023, 15, 7999.
F. Bu, Z. Sun, W. Zhou, Y. Zhang, Y. Chen, B. Ma, X. Liu, P. Liang, C. Zhong, R. Zhao, H. Li, L. Wang, T. Zhang, B. Wang, Z. Zhao, J. Zhang, W. Li, Y. S. Ibrahim, Y. Hassan, A. Elzatahry, D. Chao, D. Zhao, J. Am. Chem. Soc. 2023, 145, 24284.
T. Wang, D. Luo, Y. Zhang, Z. Zhang, J. Wang, G. Cui, X. Wang, A. Yu, Z. Chen, ACS Nano. 2021, 15, 19457.
G. Chen, Y. Xie, Y. Tang, T. Wang, Z. Wang, C. Yang, Small. 2023, 20, 2307408.
M. Shekhirev, C. E. Shuck, A. Sarycheva, Y. Gogotsi, Prog. Mater. Sci. 2021, 120, 100757.
A. Sikdar, F. Héraly, H. Zhang, S. Hall, K. Pang, M. Zhang, J. Yuan, ACS Nano. 2024, 18, 3707.
P. Wang, D. Zhao, X. Hui, Z. Qian, P. Zhang, Y. Ren, Y. Lin, Z. Zhang, L. Yin, Adv. Eng. Mater. 2021, 11, 2003069.
R. J. A. C. R.‐d. Beer, B. D. v. Zelst, A. B. Vroling, Y. B. d. Rijke, C. Ramakers, Clin. Chem. Lab. Med. 2019, 57, 659.
C. Garcia‐Diego, J. Cuellar, Chem. Eng. J. 2008, 143, 337.
R. Wang, X. Jiang, A. He, T. Xiang, C. Zhao, RSC Adv. 2015, 5, 51631.
X. Jiang, T. Xiang, Y. Xie, R. Wang, W. Zhao, S. Sun, C.‐S. Zhao, J. Mater. Sci. Mater. Med. 2016, 27, 28.
K. Wu, X. Song, S. Cui, Z. Li, Y. Jiao, C. Zhou, Appl. Surf. Sci. 2018, 451, 45.
H. Li, J. Dai, X. Yi, F. Cheng, Biomater. Adv. 2022, 140, 213055.
X. Hu, J. Tian, C. Li, H. Su, R. Qin, Y. Wang, X. Cao, P. Yang, Adv. Mater. 2020, 32, 2000128.
Y. Xu, Y. Li, W. Zhao, C. Zhao, J. Colloid Interface Sci. 2023, 631, 231.
Y. He, H. Sun, Y. Wang, Y. Yu, C. Mu, L. Chen, Chem. Eng. J. 2024, 485, 150047.
Y. Yan, H. Han, Y. Dai, H. Zhu, W. Liu, X. Tang, W. Gan, H. Li, ACS Appl. Nano Mater. 2021, 4, 11763.
H. Lin, S. Gao, C. Dai, Y. Chen, J. Shi, J. Am. Chem. Soc. 2017, 139, 16235.
W. Dai, R. Shu, F. Yang, B. Li, H. M. Johnson, S. Yu, H. Yang, Y. K. Chan, W. Yang, D. Bai, Y. Deng, Adv. Mater. 2024, 36, 2305277.
K. Rasool, M. Helal, A. Ali, C. E. Ren, Y. Gogotsi, K. A. Mahmoud, ACS Nano. 2016, 10, 3674.
F. Seidi, A. Arabi Shamsabadi, M. Dadashi Firouzjaei, M. Elliott, M. R. Saeb, Y. Huang, C. Li, H. Xiao, B. Anasori, Small. 2023, 19, 2206716.
Y. Jiang, D. Baimanov, S. Jin, J. Cheuk‐Fung Law, P. Zhao, J. Tang, J. Peng, L. Wang, K. S.‐Y. Leung, W. Sheng, S. Lin, Proc. Natl. Acad. Sci. USA. 2023, 120, 2210211120.
Y. Wu, X. Song, W. Xu, K. Sun, Z. Wang, Z. Lv, Y. Wang, Y. Wang, W. Zhong, J. Wei, H. Cai, X. Wu, Small. 2021, 17, 2101705.

52103178 National Science Foundation of China; Sixth Two-hundred Talent B plan of Sichuan University

Keywords: 2D materials; antibacterial; biomimetic porous MXene; hemoperfusion; toxins elimination

0 (Anti-Bacterial Agents)
12070-08-5 (titanium carbide)
D1JT611TNE (Titanium)

Date Created: 20240723 Date Completed: 20241107 Latest Revision: 20241107

20241114

10.1002/smll.202403271

39039981