Changes in the spectrum of biopsy-proven renal diseases over 11 years: a single-center study in China.

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  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 8701128 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-6049 (Electronic) Linking ISSN: 0886022X NLM ISO Abbreviation: Ren Fail Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: New York, N.Y. : M. Dekker, c1987-
    • Subject Terms:
      Glomerulonephritis, Membranous*/pathology ; Glomerulonephritis, Membranous*/epidemiology ; Glomerulonephritis, IGA*/pathology ; Glomerulonephritis, IGA*/epidemiology ; Glomerulosclerosis, Focal Segmental*/pathology ; Glomerulosclerosis, Focal Segmental*/epidemiology ; Nephrosis, Lipoid*/pathology ; Nephrosis, Lipoid*/epidemiology ; Kidney*/pathology; Humans ; China/epidemiology ; Male ; Retrospective Studies ; Adult ; Female ; Middle Aged ; Biopsy/statistics & numerical data ; Young Adult ; Adolescent ; Lupus Nephritis/pathology ; Lupus Nephritis/epidemiology ; Aged ; IgA Vasculitis/pathology ; IgA Vasculitis/epidemiology ; IgA Vasculitis/diagnosis ; Glomerulonephritis/pathology ; Glomerulonephritis/epidemiology ; Kidney Diseases/pathology ; Kidney Diseases/epidemiology ; Kidney Diseases/diagnosis
    • Abstract:
      Background: There have been some shifts in the frequency and distribution of biopsy-proven renal diseases in China over recent years. The aim of the study was to investigate the changing spectrum of renal diseases from the view of kidney biopsy data in a single center of China.
      Methods and Results: A total of 10,996 cases of native renal biopsies from patients aged ≥15 years old in Huashan Hospital, Fudan University, between 2008 and 2018 were analyzed retrospectively. The results showed that primary glomerular nephropathy (PGN) remained the most common biopsy-proven renal disease (69.42% of total), with IgA nephropathy (IgAN) accounting for 44.40% of PGN, membranous nephropathy (MN) for 28.55%, minimal change disease (MCD) for 13.26% and focal segmental glomerulosclerosis (FSGS) for 8.00%. During the study period, the proportion of MN in PGN appeared an increasing tendency, while that of IgAN and MCD remained stable and that of FSGS showed a decline. Secondary glomerular nephropathy (SGN) constituted 21.54% of total cases, among which the leading two diseases were lupus nephritis (LN) and Henoch-Schonlein purpura nephritis (HSN) which accounted for 41.08% and 19.11% respectively.
      Conclusions: The 11-year retrospective study revealed that PGN was the predominant histologic diagnosis among patients undergoing renal biopsy and the most frequent type of PGN remained to be IgAN, followed by MN which increased dramatically.
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    • Contributed Indexing:
      Keywords: China; Kidney disease; primary glomerular nephropathy; renal biopsy; secondary glomerular nephropathy
    • Publication Date:
      Date Created: 20240723 Date Completed: 20240723 Latest Revision: 20240726
    • Publication Date:
      20250114
    • Accession Number:
      PMC11268216
    • Accession Number:
      10.1080/0886022X.2024.2381614
    • Accession Number:
      39039852