The impact of the vitamin D and resveratrol administration on the stiffness and elasticity of T2DM rat aorta associated with the trace element and mineral levels.

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  • Additional Information
    • Source:
      Publisher: Gustav Fisher Country of Publication: Germany NLM ID: 9508274 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3252 (Electronic) Linking ISSN: 0946672X NLM ISO Abbreviation: J Trace Elem Med Biol Subsets: MEDLINE
    • Publication Information:
      Publication: Stuttgart : Gustav Fisher
      Original Publication: Stuttgart ; New York : Gustav Fischer, c1995-
    • Subject Terms:
      Resveratrol*/pharmacology ; Resveratrol*/administration & dosage ; Vitamin D*/pharmacology ; Vitamin D*/administration & dosage ; Aorta*/drug effects ; Aorta*/metabolism ; Diabetes Mellitus, Type 2*/drug therapy ; Diabetes Mellitus, Type 2*/metabolism ; Trace Elements*/pharmacology ; Elasticity*/drug effects ; Minerals*/metabolism ; Minerals*/analysis; Animals ; Rats ; Male ; Vascular Stiffness/drug effects ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Diabetes Mellitus, Experimental/chemically induced ; Rats, Sprague-Dawley ; Rats, Wistar
    • Abstract:
      Background: Type 2 diabetes mellitus (T2DM) is directly associated with increased aortic stiffness, reduced aortic elasticity, and aortic dissection, which are independent risk factors for cardiovascular death. Since Vit D and resveratrol have been reported due to their cardioprotective effects, in this study, we aim to evaluate the impact of Vit D and resveratrol treatment alone or in combination on the aortic health associated with trace element and mineral levels in a high-fructose diet/streptozotocin-induced T2DM model.
      Methods: We investigated biomechanical changes of the aorta samples via a custom-built stretcher, where trace element and mineral levels in aorta samples were determined via inductively coupled plasma mass spectrometry (ICP-MS) following acidic microwave digestion.
      Results: Vitamin D treatment ameliorated the adverse effects of T2DM on aortic stiffness, aortic elasticity, and relaxation modulus in diabetic rats. Trace element and mineral levels correlated with cardiovascular homeostasis, including Fe, Cu, Zn, Se, and Na, have been regulated upon Vit D treatment in diabetic and healthy rats. On the other hand, resveratrol treatment alone or in combination with Vit D did not show any positive effects on biomechanical properties and trace element metabolism of diabetic or healthy rats, according to our data.
      Conclusion: Vit D can be used in T2DM patients to protect their cardiovascular health and should be considered a promising targeted therapy approach via nanoparticles to target cardiovascular diseases in the future.
      Competing Interests: Declaration of Competing Interest The authors declare no conflict of interest.
      (Copyright © 2024 Elsevier GmbH. All rights reserved.)
    • Contributed Indexing:
      Keywords: Aorta; Biomechanical changes; Diabetes; Mineral; Trace element
    • Accession Number:
      Q369O8926L (Resveratrol)
      1406-16-2 (Vitamin D)
      0 (Trace Elements)
      0 (Minerals)
    • Publication Date:
      Date Created: 20240721 Date Completed: 20241206 Latest Revision: 20241206
    • Publication Date:
      20241209
    • Accession Number:
      10.1016/j.jtemb.2024.127497
    • Accession Number:
      39033582