CD150‑dependent activation of EBV‑transformed B cells induces the differentiation of peripheral blood monocytes via the secretion of multiple cytokines.

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  • Author(s): Kim HY;Kim HY; Seo IK; Seo IK; Hur DY; Hur DY
  • Source:
    International journal of molecular medicine [Int J Mol Med] 2024 Sep; Vol. 54 (3). Date of Electronic Publication: 2024 Jul 19.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9810955 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-244X (Electronic) Linking ISSN: 11073756 NLM ISO Abbreviation: Int J Mol Med Subsets: MEDLINE
    • Publication Information:
      Original Publication: Athens, Greece : D.A. Spandidos, [1998-
    • Subject Terms:
      Herpesvirus 4, Human*/immunology ; Cell Differentiation* ; B-Lymphocytes*/metabolism ; B-Lymphocytes*/immunology ; B-Lymphocytes*/virology ; Cytokines*/metabolism ; Monocytes*/metabolism ; Monocytes*/immunology ; Monocytes*/virology ; Signaling Lymphocytic Activation Molecule Family Member 1*/metabolism; Humans ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Epstein-Barr Virus Infections/metabolism ; Dendritic Cells/metabolism ; Dendritic Cells/immunology ; Dendritic Cells/virology ; Lymphocyte Activation/immunology
    • Abstract:
      CD150, also termed signaling lymphocyte activation molecule family member 1, is a cell surface receptor expressed on T cells, B cells, dendritic cells (DCs) and some tumors. Stimulation of CD150 on immune cells induces cell proliferation and cytokine production. However, the function of CD150 in Epstein‑Barr virus (EBV)‑infected B cells is still not fully understood. In the present study, CD150 expression on B cells increased rapidly following EBV infection, and various CD150 antibodies, measles viral proteins and recombinant CD150 proteins induced the secretion of multiple cytokines in both CD150 + EBV‑transformed B cells and EBV + lymphoma cells. Notably, the IL‑1α protein level showed the greatest increase among all cytokines measured. The culture supernatant containing these cytokines induced the rapid differentiation of monocytes to DCs after only 2 days in vitro , which was faster than the established DC maturation time. Furthermore, knockdown of CD150 expression led to a reduction in the secretion of multiple cytokines, and monocyte differentiation was partially inhibited by anti‑IL‑1α and anti‑granulocyte‑macrophage colony‑stimulating factor neutralizing antibodies. Collectively, the results of the present study suggest that CD150 activation triggers cytokine production in EBV‑transformed B cells, and that measles virus coinfection might affect immune responses through the production of various cytokines in EBV + lymphoma cells.
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    • Contributed Indexing:
      Keywords: B cells; CD150; Epstein‑Barr virus; cytokines; dendritic cells
    • Accession Number:
      0 (Cytokines)
      169535-43-7 (Signaling Lymphocytic Activation Molecule Family Member 1)
      0 (SLAMF1 protein, human)
    • Publication Date:
      Date Created: 20240719 Date Completed: 20240719 Latest Revision: 20240725
    • Publication Date:
      20240726
    • Accession Number:
      PMC11265835
    • Accession Number:
      10.3892/ijmm.2024.5403
    • Accession Number:
      39027993