Agonist-dependent action of the juvenile hormone receptor.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101635599 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2214-5753 (Electronic) NLM ISO Abbreviation: Curr Opin Insect Sci Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier
    • Subject Terms:
      Juvenile Hormones*/metabolism; Animals ; Signal Transduction ; Basic Helix-Loop-Helix Transcription Factors/metabolism ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Basic Helix-Loop-Helix Transcription Factors/chemistry
    • Abstract:
      Juvenile hormone (JH) signaling is realized at the gene regulatory level by receptors of the bHLH-PAS transcription factor family. The sesquiterpenoid hormones and their synthetic mimics are agonist ligands of a unique JH receptor (JHR) protein, methoprene-tolerant (MET). Upon binding an agonist to its PAS-B cavity, MET dissociates from a cytoplasmic chaperone complex including HSP83 and concomitantly switches to a bHLH-PAS partner taiman, forming a nuclear, transcriptionally active JHR heterodimer. This course of events resembles the vertebrate aryl hydrocarbon receptor (AHR), activated by a plethora of endogenous and synthetic compounds. Like in AHR, the pliable PAS-B cavity of MET adjusts to diverse ligands and binds them through similar mechanisms. Despite recent progress, we only begin to discern agonist-induced conformational shifts within the PAS-B domain, with the ultimate goal of understanding how these localized changes stimulate the assembly of the active JHR complex and, thus, fully grasp the mechanism of JHR signaling.
      Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships that may be considered as potential competing interests: Marek Jindra and David Sedlak are co-founders of Preagon Biotech, a company aiming to develop specific JHR agonists as selective insecticides.
      (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
    • Accession Number:
      0 (Juvenile Hormones)
      0 (Basic Helix-Loop-Helix Transcription Factors)
    • Publication Date:
      Date Created: 20240718 Date Completed: 20240912 Latest Revision: 20240913
    • Publication Date:
      20240914
    • Accession Number:
      10.1016/j.cois.2024.101234
    • Accession Number:
      39025365