Phosphoglycerate kinase acts in tumour angiogenesis as a disulphide reductase.

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    • Subject Terms:
      REGULATION of neovascularization; TUMOR blood vessels; BLOOD-vessel development; CANCER treatment; SARCOMA; ENZYMES
    • Abstract:
      Shows that plasmin reductase isolated from conditioned medium of fibrosarcoma cells is the glycolytic enzyme phosphoglycerate kinase. Administration of phosphoglycerate kinase to tumor-bearing mice causing an increase in plasma levels of angiostatin and a decrease in tumor vascularity and rate of tumor growth; Indication that phosphoglycerate kinase functions in glycolysis and is secreted by tumor cells and participates in the angiogenic process as a disulphide reductase.