Natural pyrethrins induced developmental toxicity of zebrafish swim bladder in vivo and genotoxicity of lung cells in vitro.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 8712158 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3177 (Electronic) Linking ISSN: 08872333 NLM ISO Abbreviation: Toxicol In Vitro Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford ; New York : Pergamon Press, c1987-
    • Subject Terms:
      Zebrafish* ; Air Sacs*/drug effects ; Pyrethrins*/toxicity ; DNA Damage* ; Lung*/drug effects ; Insecticides*/toxicity ; Embryo, Nonmammalian*/drug effects; Animals ; Humans ; Apoptosis/drug effects ; A549 Cells ; Cell Survival/drug effects ; Heart Rate/drug effects
    • Abstract:
      Natural pyrethrins (NPs) are insecticidal compounds isolated and extracted from pyrethrum flowers and are primarily use to control sanitary pests. The lungs become the main target after exposure, and its use may pose potential hazards to respiratory health. Therefore, in this paper, the toxic effects of NPs on human lung cells A549 were investigated and the risk of respiratory toxicity of NPs was studied using zebrafish swim bladder as a model. The results showed that NPs induced cytotoxicity, caused oxidative DNA damage and triggered mitochondria-mediated apoptosis. In addition, exposure to NPs decreased zebrafish embryo survival, hatchability, and heartbeat, and may inhibit normal swim bladder development by disrupting Wnt and Hedgehog signaling pathways. In conclusion, our results suggest that NPs can induce cytotoxicity in A549 in vitro and developmental toxicity in zebrafish in vivo. This study provides a conceptual basis for understanding the mechanisms of toxicity of NPs and assessing respiratory health risks in humans.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Contributed Indexing:
      Keywords: A549 cells; Natural pyrethrins; Respiratory toxicity risk; Zebrafish swim bladder
    • Accession Number:
      0 (Pyrethrins)
      0 (Insecticides)
    • Publication Date:
      Date Created: 20240718 Date Completed: 20240905 Latest Revision: 20240905
    • Publication Date:
      20240906
    • Accession Number:
      10.1016/j.tiv.2024.105896
    • Accession Number:
      39025157