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Comparative pharmacology and abuse potential of oral dexamphetamine and lisdexamfetamine-A literature review.
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- Author(s): Kämmerer W;Kämmerer W
- Source:Human psychopharmacology [Hum Psychopharmacol] 2024 Nov; Vol. 39 (6), pp. e2910. Date of Electronic Publication: 2024 Jul 18.
- Publication Type:Journal Article; Review; Comparative Study
- Language:English
- Additional Information
- Source: Publisher: Wiley & Sons Country of Publication: England NLM ID: 8702539 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1077 (Electronic) Linking ISSN: 08856222 NLM ISO Abbreviation: Hum Psychopharmacol Subsets: MEDLINE
- Publication Information: Original Publication: Chichester, Sussex, England : Wiley & Sons, c1986-
- Subject Terms: Central Nervous System Stimulants*/administration & dosage ; Central Nervous System Stimulants*/adverse effects ; Central Nervous System Stimulants*/pharmacokinetics ; Dextroamphetamine*/administration & dosage ; Dextroamphetamine*/adverse effects ; Dextroamphetamine*/pharmacokinetics ; Lisdexamfetamine Dimesylate*/administration & dosage ; Lisdexamfetamine Dimesylate*/adverse effects ; Lisdexamfetamine Dimesylate*/pharmacokinetics; Animals ; Humans ; Administration, Oral ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Dose-Response Relationship, Drug ; Prodrugs/administration & dosage ; Prodrugs/adverse effects ; Prodrugs/pharmacokinetics ; Substance-Related Disorders
- Abstract: Objective: To compare the pharmacology and abuse potential of oral dexamphetamine and lisdexamfetamine (LDX).
Methods: A search of Medline and Embase was conducted to identify relevant articles for this literature review.
Results: Dexamphetamine and LDX, a prodrug of dexamphetamine, are indicated for the treatment of attention-deficit/hyperactivity disorder. It has been suggested that LDX may have a reduced potential for oral abuse compared to immediate-release dexamphetamine. As a prodrug, LDX has the same pharmacodynamic properties as dexamphetamine. A study in healthy adults showed that the pharmacokinetic profile of dexamphetamine following oral administration of LDX is essentially identical to that of an equimolar dose of dexamphetamine administered 1 h later. In addition, dexamphetamine produced subjective drug liking effects comparable to those produced by LDX. LDX showed linear dose proportional pharmacokinetics up to a dose of 250 mg, indicating a lack of overdose protection at supratherapeutic doses. Furthermore, the exposure to dexamphetamine released from LDX may be prolonged by the consumption of alkalizing agents.
Conclusions: The available evidence from pharmacodynamic, pharmacokinetic and abuse liability studies suggests a comparable potential for oral abuse of dexamphetamine and LDX.
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- Accession Number: 0 (Central Nervous System Stimulants)
TZ47U051FI (Dextroamphetamine)
SJT761GEGS (Lisdexamfetamine Dimesylate)
0 (Prodrugs) - Publication Date: Date Created: 20240718 Date Completed: 20241113 Latest Revision: 20241202
- Publication Date: 20241204
- Accession Number: 10.1002/hup.2910
- Accession Number: 39024047
- Source:
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