Post-discharge spirometry evaluation in patients recovering from moderate-to-critical COVID-19: a cross-sectional study.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
      COVID-19*/epidemiology ; COVID-19*/diagnosis ; COVID-19*/physiopathology ; Spirometry*/methods ; Patient Discharge*; Humans ; Male ; Female ; Cross-Sectional Studies ; Middle Aged ; Malaysia/epidemiology ; Adult ; SARS-CoV-2/isolation & purification ; Aged ; Lung/physiopathology ; Lung/diagnostic imaging ; Prevalence
    • Abstract:
      Understanding the prevalence of abnormal lung function and its associated factors among patients recovering from COVID-19 is crucial for enhancing post-COVID care strategies. This study primarily aimed to determine the prevalence and types of spirometry abnormalities among post-COVID-19 patients in Malaysia, with a secondary objective of identifying its associated factors. Conducted at the COVID-19 Research Clinic, Faculty of Medicine, University Technology MARA, from March 2021 to December 2022, this study included patients at least three months post-discharge from hospitals following moderate-to-critical COVID-19. Of 408 patients studied, abnormal spirometry was found in 46.8%, with 28.4% exhibiting a restrictive pattern, 17.4% showing preserved ratio impaired spirometry (PRISm), and 1.0% displaying an obstructive pattern. Factors independently associated with abnormal spirometry included consolidation on chest X-ray (OR 8.1, 95% CI 1.75-37.42, p = 0.008), underlying cardiovascular disease (OR 3.5, 95% CI 1.19-10.47, p = 0.023), ground-glass opacity on chest X-ray (OR 2.6, 95% CI 1.52-4.30, p < 0.001), and oxygen desaturation during the 6-min walk test (OR 1.9, 95% CI 1.20-3.06, p = 0.007). This study highlights that patients recovering from moderate-to-critical COVID-19 often exhibit abnormal spirometry, notably a restrictive pattern and PRISm. Routine spirometry screening for high-risk patients is recommended.
      (© 2024. The Author(s).)
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    • Grant Information:
      F05/RISE/2089/2021 Universiti Malaysia Sarawak; F05/RISE/2089/2021 Universiti Malaysia Sarawak; F05/RISE/2089/2021 Universiti Malaysia Sarawak; F05/RISE/2089/2021 Universiti Malaysia Sarawak; F05/RISE/2089/2021 Universiti Malaysia Sarawak; GI/F05/LFM/2021 Lung Foundation of Malaysia; GI/F05/LFM/2021 Lung Foundation of Malaysia; GI/F05/LFM/2021 Lung Foundation of Malaysia; GI/F05/LFM/2021 Lung Foundation of Malaysia; GI/F05/LFM/2021 Lung Foundation of Malaysia; GI/F05/LFM/2021 Lung Foundation of Malaysia; GI/F05/LFM/2021 Lung Foundation of Malaysia; IRG/F05/PPKP/85316/2022 Persatuan Pendidikan Kesihatan Paru-Paru; IRG/F05/PPKP/85316/2022 Persatuan Pendidikan Kesihatan Paru-Paru; IRG/F05/PPKP/85316/2022 Persatuan Pendidikan Kesihatan Paru-Paru; IRG/F05/PPKP/85316/2022 Persatuan Pendidikan Kesihatan Paru-Paru; IRG/F05/PPKP/85316/2022 Persatuan Pendidikan Kesihatan Paru-Paru; IRG/F05/PPKP/85316/2022 Persatuan Pendidikan Kesihatan Paru-Paru; IRG/F05/PPKP/85316/2022 Persatuan Pendidikan Kesihatan Paru-Paru; GI/F05/CMSB/2021 Compass Medical Sdn Bhd; GI/F05/CMSB/2021 Compass Medical Sdn Bhd; GI/F05/CMSB/2021 Compass Medical Sdn Bhd; GI/F05/CMSB/2021 Compass Medical Sdn Bhd; GI/F05/CMSB/2021 Compass Medical Sdn Bhd; GI/F05/CMSB/2021 Compass Medical Sdn Bhd; GI/F05/CMSB/2021 Compass Medical Sdn Bhd; IRG/F05/APMSB/85317/2022 Aliran Pasifik (M) Sdn Bhd; IRG/F05/APMSB/85317/2022 Aliran Pasifik (M) Sdn Bhd; IRG/F05/APMSB/85317/2022 Aliran Pasifik (M) Sdn Bhd; IRG/F05/APMSB/85317/2022 Aliran Pasifik (M) Sdn Bhd; IRG/F05/APMSB/85317/2022 Aliran Pasifik (M) Sdn Bhd; IRG/F05/APMSB/85317/2022 Aliran Pasifik (M) Sdn Bhd; IRG/F05/APMSB/85317/2022 Aliran Pasifik (M) Sdn Bhd; 100 - 3/2/3JLD[25] Selangor State Government; 100 - 3/2/3JLD[25] Selangor State Government
    • Contributed Indexing:
      Keywords: COVID-19; Obstructive; PRISm; Radio-imaging; Restrictive; Spirometry
    • Publication Date:
      Date Created: 20240716 Date Completed: 20240716 Latest Revision: 20240801
    • Publication Date:
      20240801
    • Accession Number:
      PMC11252397
    • Accession Number:
      10.1038/s41598-024-67536-2
    • Accession Number:
      39013943