High Obesity Indices Are Associated with Gastroesophageal Reflux Disease, but Low Obesity Indices Are Associated with Peptic Ulcer Disease in a Large Taiwanese Population Study.

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  • Additional Information
    • Source:
      Publisher: Karger Country of Publication: Switzerland NLM ID: 101469429 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1662-4033 (Electronic) Linking ISSN: 16624025 NLM ISO Abbreviation: Obes Facts Subsets: MEDLINE
    • Publication Information:
      Original Publication: Basel : Karger
    • Subject Terms:
      Gastroesophageal Reflux*/epidemiology ; Obesity*/epidemiology ; Body Mass Index* ; Peptic Ulcer*/epidemiology ; Waist-Hip Ratio*; Humans ; Male ; Taiwan/epidemiology ; Female ; Middle Aged ; Adult ; Prevalence ; Triglycerides/blood ; Waist-Height Ratio ; Risk Factors ; Intra-Abdominal Fat ; Adiposity ; Lipid Accumulation Product
    • Abstract:
      Introduction: Gastroesophageal reflux disease (GERD) and peptic ulcer disease (PUD) are prevalent in Taiwan. Few studies have investigated the associations between obesity indices with GERD and PUD simultaneously. This study aimed to investigate the correlations among obesity indices with GERD and PUD in a large cohort of participants, around 120,000, in the Taiwan Biobank (TWB).
      Methods: A total of 121,583 participants (male: 43,698; female: 77,885; mean age 49.9 ± 11.0 years) were included to analyze the associations among obesity indices, including body mass index (BMI), waist-hip ratio (WHR), waist-to-height ratio (WHtR), body roundness index (BRI), abdominal volume index (AVI), lipid accumulation product (LAP), visceral adiposity index (VAI), and triglyceride-glucose index (TyG index), with GERD and PUD. Self-reported GERD and PUD were obtained by questionnaires. Multivariate logistic regression analysis was employed to analyze the relationship between obesity indices with GERD and PUD.
      Results: The prevalence of GERD and PUD was 13.7% and 14.6%, respectively. After multivariable analysis, high WHR (odds ratio [OR] = 1.009, p < 0.001), WHtR (OR = 1.005, p = 0.003), BRI (OR = 1.022, p = 0.005), AVI (OR = 1.013, p < 0.001), LAP (OR = 1.001, p < 0.001), TyG index (OR = 1.068, p < 0.001), and VAI (OR = 1.013, p = 0.002) were significantly associated with GERD, except BMI (p = 0.384). On the other hand, low BMI (OR = 0.984; p < 0.001) and AVI (OR = 0.994; p = 0.036) were significantly associated with PUD. However, the values of WHR (p = 0.151), WHtR (p = 0.304), BRI (p = 0.452), LAP (p = 0.799), VAI (p = 0.347), and TyG index (p = 0.642) were not.
      Conclusion: This study found that high obesity indices are associated with GERD, but low obesity indices are associated with PUD in a large Taiwanese population study. Our findings may alert physicians to notice that different obesity index may be associated with different gastrointestinal disorder.
      (© 2024 The Author(s). Published by S. Karger AG, Basel.)
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    • Contributed Indexing:
      Keywords: Gastroesophageal reflux disease; Obesity indices; Peptic ulcer disease; Taiwan biobank
    • Accession Number:
      0 (Triglycerides)
    • Publication Date:
      Date Created: 20240715 Date Completed: 20241007 Latest Revision: 20241009
    • Publication Date:
      20241009
    • Accession Number:
      PMC11458163
    • Accession Number:
      10.1159/000540281
    • Accession Number:
      39008955