Local Cutaneous Scrotal Involvement of Paratesticular Mesothelioma.

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  • Additional Information
    • Source:
      Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 7911005 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1533-0311 (Electronic) Linking ISSN: 01931091 NLM ISO Abbreviation: Am J Dermatopathol Subsets: MEDLINE
    • Publication Information:
      Publication: Hagerstown, MD : Lippincott Williams & Wilkins
      Original Publication: New York, Masson Publishing USA.
    • Subject Terms:
      Scrotum*/pathology ; Mesothelioma*/pathology ; Testicular Neoplasms*/pathology ; Skin Neoplasms*/pathology ; Mesothelioma, Malignant*/pathology; Humans ; Male ; Aged ; Orchiectomy ; Immunohistochemistry
    • Abstract:
      Abstract: Paratesticular mesothelioma (malignant mesothelioma arising from the tunica vaginalis of the testis) represents a small proportion of mesothelial neoplasms, and cutaneous involvement by paratesticular mesothelioma is very rare. Cutaneous involvement can manifest as scrotal subcutaneous nodules from regional spread, distant metastasis, or direct extension through surgical scars. Mesothelioma has 3 histopathologic classifications that include epithelioid, biphasic, and sarcomatoid, which is rarely seen in paratesticular mesothelioma. Given the rarity of this condition, cutaneous mesothelioma may be misdiagnosed as histologic mimics, such as metastatic adenocarcinoma or adnexal neoplasms; thus, appropriate immunohistochemical workup and clinical correlation are required to make an accurate diagnosis. In this case, a 75-year-old man with a history of paratesticular mesothelioma, status postorchiectomy, presented with right-sided scrotal swelling, erythema, and subcutaneous nodules. These nodules were identified as local recurrence with cutaneous involvement by paratesticular mesothelioma on histopathologic examination. This case highlights the clinical and histopathologic features of this diagnosis and underscores the importance of dermatopathologists being aware of this condition to ensure accurate diagnosis.
      Competing Interests: The authors declare no conflicts of interest.
      (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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    • Publication Date:
      Date Created: 20240715 Date Completed: 20240918 Latest Revision: 20240918
    • Publication Date:
      20240919
    • Accession Number:
      10.1097/DAD.0000000000002802
    • Accession Number:
      39008503