"Cardiac glycosides"-quo vaditis?-past, present, and future?

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  • Additional Information
    • Source:
      Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE
    • Publication Information:
      Original Publication: Berlin, New York, Springer Verlag.
    • Subject Terms:
      Cardiac Glycosides*/therapeutic use ; Cardiac Glycosides*/pharmacology; Humans ; Animals ; Heart Failure/drug therapy ; Heart Failure/history ; Digitalis Glycosides/therapeutic use ; Digitalis Glycosides/history ; Digitalis Glycosides/pharmacology ; Sodium-Potassium-Exchanging ATPase/antagonists & inhibitors ; Sodium-Potassium-Exchanging ATPase/metabolism ; Atrial Fibrillation/drug therapy
    • Abstract:
      Up to date, digitalis glycosides, also known as "cardiac glycosides", are inhibitors of the Na + /K + -ATPase. They have a long-standing history as drugs used in patients suffering from heart failure and atrial fibrillation despite their well-known narrow therapeutic range and the intensive discussions on their raison d'être for these indications. This article will review the history and key findings in basic and clinical research as well as potentially overseen pros and cons of these drugs.
      Competing Interests: Declarations. Ethical approval: Not applicable. Competing interests: The authors declare no competing interests.
      (© 2024. The Author(s).)
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    • Grant Information:
      03INT703AB Bundesministerium für Bildung und Forschung; 453989101 Deutsche Forschungsgemeinschaft
    • Contributed Indexing:
      Keywords: Atrial fibrillation; Cancer; Cardiac glycosides; Digitalis glycosides; Digitoxin; Digoxin; Heart failure; Metabolism; NKA inhibitors; Na+/K+-ATPase; Toxicity
    • Accession Number:
      0 (Cardiac Glycosides)
      0 (Digitalis Glycosides)
      EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
    • Publication Date:
      Date Created: 20240715 Date Completed: 20241121 Latest Revision: 20241129
    • Publication Date:
      20241202
    • Accession Number:
      PMC11582269
    • Accession Number:
      10.1007/s00210-024-03285-3
    • Accession Number:
      39007928