Injectable Tissue Adhesive Microgel Composite Containing Antifibrotic Drug for Vocal Fold Scarring.

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  • Additional Information
    • Source:
      Publisher: ACS Publications Country of Publication: United States NLM ID: 101729147 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2576-6422 (Electronic) Linking ISSN: 25766422 NLM ISO Abbreviation: ACS Appl Bio Mater Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : ACS Publications, [2018]-
    • Subject Terms:
      Vocal Cords*/pathology ; Vocal Cords*/drug effects ; Tissue Adhesives*/chemistry ; Tissue Adhesives*/pharmacology ; Biocompatible Materials*/chemistry ; Biocompatible Materials*/pharmacology ; Cicatrix*/drug therapy ; Cicatrix*/pathology ; Materials Testing*; Humans ; Cell Proliferation/drug effects ; Particle Size ; Microgels/chemistry ; Antifibrotic Agents/chemistry ; Antifibrotic Agents/pharmacology ; Fibroblasts/drug effects ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Alginates/chemistry ; Cell Movement/drug effects ; Polysaccharides, Bacterial ; Pyridones
    • Abstract:
      Vocal fold (VF) scarring, a complex problem in laryngology, results from injury and inflammation of the layered architecture of the VFs. The resultant voice hoarseness, for which successful therapeutic options are currently limited, affects the patient's quality of life. A promising strategy to reverse this disorder is the use of antifibrotic drugs. The present study proposes a novel microbead-embedded injectable hydrogel that can sustain the release of the anti-fibrotic drug pirfenidone (PFD) for vocal fold scarring. Microbeads were developed using sodium alginate and gelatin, which were further embedded into a biomimetic and tissue adhesive gellan gum (GG) hydrogel. The microbead-embedded hydrogel exhibited improved injectability, viscoelasticity, tissue adhesiveness, degradability, and swelling compared to the hydrogel without beads. Additionally, the bead-embedded hydrogel could sustain the release of the PFD for a week. In vitro studies showed that the drug-loaded hydrogel could reduce the migration and proliferation of fibroblast cells in a dose-dependent manner. In summary, this study demonstrates the potential of a PFD-loaded injectable hydrogel with enhanced viscoelastic and tissue-adhesive properties for vocal fold scarring applications.
    • Contributed Indexing:
      Keywords: Antifibrotic; Gellan Gum; Microgel; Pirfenidone; Tissue Adhesive; Vocal Fold
    • Accession Number:
      0 (Tissue Adhesives)
      0 (Biocompatible Materials)
      0 (Microgels)
      0 (Antifibrotic Agents)
      D7NLD2JX7U (pirfenidone)
      0 (Hydrogels)
      0 (Alginates)
      7593U09I4D (gellan gum)
      0 (Polysaccharides, Bacterial)
      0 (Pyridones)
    • Publication Date:
      Date Created: 20240715 Date Completed: 20240819 Latest Revision: 20240819
    • Publication Date:
      20240819
    • Accession Number:
      10.1021/acsabm.4c00422
    • Accession Number:
      39007499