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Fluoride, teeth and bone.
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- Author(s): Smith GE
- Source:
The Medical journal of Australia [Med J Aust] 1985 Sep 30; Vol. 143 (7), pp. 283-6.
- Publication Type:
Journal Article; Review
- Language:
English
- Additional Information
- Source:
Publisher: Australasian Medical Publishing Co Country of Publication: Australia NLM ID: 0400714 Publication Model: Print Cited Medium: Print ISSN: 0025-729X (Print) Linking ISSN: 0025729X NLM ISO Abbreviation: Med J Aust Subsets: MEDLINE
- Publication Information:
Publication: : Pyrmont, NSW : Australasian Medical Publishing Co.
Original Publication: Sydney : Australasian Medical Pub. Co.
- Subject Terms:
- Abstract:
Fluoride therapy has been credited with remarkable success in reducing the incidence of tooth decay. Medium to high doses of fluoride have been used in the treatment of osteoporosis. The precise mode of action of fluoride on teeth and bone has yet to be elucidated. It is often assumed that, except in rare circumstances, plasma and extracellular fluid levels of ionic fluoride will not reach concentrations capable of interfering with the normal functioning of human cells. However, fluoride accumulates in skeletal tissues and may be concentrated in the surface layers of the lacunae and canaliculae of bone. Such a hypothetical mechanism may help to clarify the pathogenesis of the osseous lesions in skeletal fluorosis. This hypothesis should be tested in view of recent findings which show that sodium fluoride has a genotoxic effect on embryonic cell culture lines, and can interfere with DNA synthesis in human oral keratinocytes.
- Number of References:
22
- Accession Number:
0 (Minerals)
Q80VPU408O (Fluorides)
- Publication Date:
Date Created: 19850930 Date Completed: 19851030 Latest Revision: 20210107
- Publication Date:
20240829
- Accession Number:
10.5694/j.1326-5377.1985.tb123008.x
- Accession Number:
3900656
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