Arsenic exposure and oxidative damage to lipid, DNA, and protein among general Chinese adults: A repeated-measures cross-sectional and longitudinal study.

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  • Additional Information
    • Source:
      Publisher: IOS Press Country of Publication: Netherlands NLM ID: 100967627 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1001-0742 (Print) Linking ISSN: 10010742 NLM ISO Abbreviation: J Environ Sci (China) Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : IOS Press
      Original Publication: Beijing : Editorial Dept. of Journal of Environmental Sciences (China), 1989-
    • Subject Terms:
      Arsenic*/toxicity ; Environmental Exposure*/adverse effects ; Oxidative Stress*/drug effects; Adult ; Female ; Humans ; Male ; Middle Aged ; 8-Hydroxy-2'-Deoxyguanosine ; Biomarkers/urine ; China ; Cross-Sectional Studies ; DNA Damage ; East Asian People ; Environmental Pollutants/toxicity ; Lipid Peroxidation/drug effects ; Longitudinal Studies
    • Abstract:
      Arsenic-related oxidative stress and resultant diseases have attracted global concern, while longitudinal studies are scarce. To assess the relationship between arsenic exposure and systemic oxidative damage, we performed two repeated measures among 5236 observations (4067 participants) in the Wuhan-Zhuhai cohort at the baseline and follow-up after 3 years. Urinary total arsenic, biomarkers of DNA oxidative damage (8-hydroxy-2'-deoxyguanosine (8-OHdG)), lipid peroxidation (8-isoprostaglandin F2alpha (8-isoPGF2α)), and protein oxidative damage (protein carbonyls (PCO)) were detected for all observations. Here we used linear mixed models to estimate the cross-sectional and longitudinal associations between arsenic exposure and oxidative damage. Exposure-response curves were constructed by utilizing the generalized additive mixed models with thin plate regressions. After adjusting for potential confounders, arsenic level was significantly and positively related to the levels of global oxidative damage and their annual increased rates in dose-response manners. In cross-sectional analyses, each 1% increase in arsenic level was associated with a 0.406% (95% confidence interval (CI): 0.379% to 0.433%), 0.360% (0.301% to 0.420%), and 0.079% (0.055% to 0.103%) increase in 8-isoPGF2α, 8-OHdG, and PCO, respectively. More importantly, arsenic was further found to be associated with increased annual change rates of 8-isoPGF2α (β: 0.147; 95% CI: 0.130 to 0.164), 8-OHdG (0.155; 0.118 to 0.192), and PCO (0.050; 0.035 to 0.064) in the longitudinal analyses. Our study suggested that arsenic exposure was not only positively related with global oxidative damage to lipid, DNA, and protein in cross-sectional analyses, but also associated with annual increased rates of these biomarkers in dose-dependent manners.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2023. Published by Elsevier B.V.)
    • Contributed Indexing:
      Keywords: 8-OHdG; 8-isoPGF2α; Arsenic; Oxidative damage; Oxidative stress; Protein carbonyls (PCO)
    • Accession Number:
      88847-89-6 (8-Hydroxy-2'-Deoxyguanosine)
      N712M78A8G (Arsenic)
      0 (Biomarkers)
      0 (Environmental Pollutants)
    • Publication Date:
      Date Created: 20240713 Date Completed: 20240713 Latest Revision: 20240715
    • Publication Date:
      20240716
    • Accession Number:
      10.1016/j.jes.2023.12.002
    • Accession Number:
      39003056