Sex moderates the effect of anhedonia on parietal alpha asymmetry.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford : Pergamon Press
    • Subject Terms:
      Anhedonia*/physiology ; Alpha Rhythm*/physiology ; Parietal Lobe*/physiopathology ; Parietal Lobe*/diagnostic imaging ; Sex Characteristics*; Humans ; Female ; Male ; Adult ; Young Adult ; Electroencephalography ; Adolescent ; Psychiatric Status Rating Scales ; Functional Laterality/physiology
    • Abstract:
      Anhedonia, a transdiagnostic symptom present in many neuropsychiatric disorders, differs in males and females. Parietal EEG alpha asymmetry is associated with reduced arousal and low positive emotionality, and is, therefore, a promising neurophysiologic biomarker of anhedonia. To date, however, no prior studies have determined whether this measure captures sex differences in anhedonic expression. This preliminary study (N = 36) investigated whether anhedonia severity is associated with EEG resting-state parietal alpha asymmetry in adults and whether sex moderates this relationship. Results showed that there was a significant moderating effect of sex such that, only for females, higher levels of anhedonia were associated with increased parietal alpha asymmetry. These findings suggest that parietal alpha asymmetry is a promising biomarker of anhedonia severity in female adults and reinforces the need to account for sex differences in future research.
      Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
      (Copyright © 2024 Elsevier Ltd. All rights reserved.)
    • Grant Information:
      I01 CX002456 United States CX CSRD VA; I01 CX002655 United States CX CSRD VA
    • Contributed Indexing:
      Keywords: Anhedonia; EEG; Parietal alpha asymmetry; Sexual dimorphism
    • Publication Date:
      Date Created: 20240713 Date Completed: 20240903 Latest Revision: 20241210
    • Publication Date:
      20241210
    • Accession Number:
      10.1016/j.jpsychires.2024.06.051
    • Accession Number:
      39002532