The role of integrins in brain health and neurodegenerative diseases.

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  • Author(s): Cui Y;Cui Y; Rolova T; Rolova T; Fagerholm SC; Fagerholm SC
  • Source:
    European journal of cell biology [Eur J Cell Biol] 2024 Sep; Vol. 103 (3), pp. 151441. Date of Electronic Publication: 2024 Jul 06.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Germany NLM ID: 7906240 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1618-1298 (Electronic) Linking ISSN: 01719335 NLM ISO Abbreviation: Eur J Cell Biol Subsets: MEDLINE
    • Publication Information:
      Publication: Jena, Germany : Elsevier
      Original Publication: Stuttgart : Wissenschaftliche Verlagsgesellschaft, <1979-1997>
    • Subject Terms:
    • Abstract:
      Integrins are heterodimeric membrane proteins expressed on the surface of most cells. They mediate adhesion and signaling processes relevant for a wealth of physiological processes, including nervous system development and function. Interestingly, integrins are also recognized therapeutic targets for inflammatory diseases, such as multiple sclerosis. Here, we discuss the role of integrins in brain development and function, as well as in neurodegenerative diseases affecting the brain (Alzheimer's disease, multiple sclerosis, stroke). Furthermore, we discuss therapeutic targeting of these adhesion receptors in inflammatory diseases of the brain.
      Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier GmbH.. All rights reserved.)
    • Contributed Indexing:
      Keywords: Brain; Integrin; Multiple sclerosis; Stroke, Alzheimer's disease
    • Accession Number:
      0 (Integrins)
    • Publication Date:
      Date Created: 20240713 Date Completed: 20240815 Latest Revision: 20240924
    • Publication Date:
      20240924
    • Accession Number:
      10.1016/j.ejcb.2024.151441
    • Accession Number:
      39002282