The impact of consanguinity on the design of iPSC banks.

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  • Author(s): Alkuraya IF;Alkuraya IF; De Vol EB; De Vol EB
  • Source:
    Stem cell reports [Stem Cell Reports] 2024 Aug 13; Vol. 19 (8), pp. 1043-1047. Date of Electronic Publication: 2024 Jul 11.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
    • Publication Information:
      Original Publication: [Cambridge, MA] : Cell Press, c 2013-
    • Subject Terms:
      Induced Pluripotent Stem Cells*/cytology ; Induced Pluripotent Stem Cells*/metabolism ; Consanguinity*; Humans ; HLA Antigens/genetics ; Biological Specimen Banks ; Homozygote
    • Abstract:
      The effect of consanguinity on identifying universal induced pluripotent stem cell (iPSC) donors, i.e., homozygous for the major human leukocyte antigen (HLA) loci, is unknown. The discovery sample size was calculated in a consanguineous population using a method (1qF) based on the inbreeding coefficient. The result was orders of magnitude smaller compared to the standard method.
      Competing Interests: Declaration of interests The authors declare no competing interests.
      (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
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    • Accession Number:
      0 (HLA Antigens)
    • Publication Date:
      Date Created: 20240712 Date Completed: 20240814 Latest Revision: 20240906
    • Publication Date:
      20240906
    • Accession Number:
      PMC11368693
    • Accession Number:
      10.1016/j.stemcr.2024.06.004
    • Accession Number:
      38996491