White matter substrates underlying morphological awareness deficit in Chinese children with developmental dyslexia.

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  • Additional Information
    • Source:
      Publisher: Pergamon Press Country of Publication: England NLM ID: 8211617 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4216 (Electronic) Linking ISSN: 02785846 NLM ISO Abbreviation: Prog Neuropsychopharmacol Biol Psychiatry Subsets: MEDLINE
    • Publication Information:
      Original Publication: Oxford ; New York : Pergamon Press, c1982-
    • Subject Terms:
      Dyslexia*/diagnostic imaging ; Dyslexia*/pathology ; White Matter*/diagnostic imaging ; White Matter*/pathology ; Diffusion Tensor Imaging*; Humans ; Male ; Female ; Child ; Awareness ; China ; Diffusion Magnetic Resonance Imaging ; Neuropsychological Tests ; Anisotropy ; East Asian People
    • Abstract:
      Background: Morphological awareness (MA) deficit is strongly associated with Chinese developmental dyslexia (DD). However, little is known about the white matter substrates underlying the MA deficit in Chinese children with DD.
      Methods: In the current study, 34 Chinese children with DD and 42 typical developmental (TD) children were recruited to complete a diffusion magnetic resonance imaging scan and cognitive tests for MA. We conducted linear regression to test the correlation between MA and DTI metrics, the structural abnormalities of the tracts related to MA, and the interaction effect of DTI metrics by group on MA.
      Results: First, MA was significant related to the right inferior occipito-frontal fascicle (IFO) and inferior longitudinal fsciculus (ILF), the bilateral thalamo-occipital (T_OCC) and the left arcuate fasciculus (AF); second, compared to TD children, Chinese children with DD had lower axial diffusivity (AD) in the right IFO and T_OCC; third, there were significant interactions between metrics (fractional anisotropy (FA) and radial diffusivity (RD)) of the right IFO and MA in groups. The FA and RD of the right IFO were significantly associated with MA in children with DD but not in TD children.
      Conclusion: In conclusion, compared to TD children, Chinese children with DD had axonal degeneration not only in the ventral tract (the right IFO) but also the visuospatial tract (the right T_OCC) which were associated with their MA deficit. And Chinese MA involved not only the ventral tracts, but also the visuospatial pathway and dorsal tracts.
      Competing Interests: Declaration of competing interest The authors declare that they have no competing interests.
      (Copyright © 2024 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Developmental dyslexia; Diffusion-weighted imaging; Morphological awareness; Tractography
    • Publication Date:
      Date Created: 20240711 Date Completed: 20240725 Latest Revision: 20241015
    • Publication Date:
      20241016
    • Accession Number:
      10.1016/j.pnpbp.2024.111083
    • Accession Number:
      38992486