Preparation of imidazolium ionic liquid functionalized paper membrane for selective extraction of caffeic acid and its structural and functional analogues from Taraxaci Herba.

Publisher: Wiley Country of Publication: England NLM ID: 8610241 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-0801 (Electronic) Linking ISSN: 02693879 NLM ISO Abbreviation: Biomed Chromatogr Subsets: MEDLINE

Publication: 1990- : Chichester : Wiley
Original Publication: London : Heyden & Son, c1986-1990

Caffeic Acids*/chemistry ; Caffeic Acids*/isolation & purification ; Ionic Liquids*/chemistry ; Imidazoles*/chemistry ; Membranes, Artificial*; Paper ; Solid Phase Extraction/methods ; Limit of Detection ; Chromatography, High Pressure Liquid/methods ; Plant Extracts/chemistry ; Reproducibility of Results

In the search for pharmaceutically active compounds from natural products, it is crucial and challenging to develop separation or purification methods that target not only structurally similar compounds but also those with specific pharmaceutical functions. The adsorption-based method is widely employed in this field and holds potential for this application, given the diverse range of functional monomers that can be chosen based on structural or functional selectivity. In this work, an imidazolium ionic liquid (IL) modified paper membrane was synthesized via microwave reaction. Caffeic acid (CA), with potential interactions with imidazolium IL and a representative component of phenolic acids in Taraxaci Herba, was chosen as a target compound. After optimization of synthesis and extraction parameters, the resulting extraction membrane could be used to quantitatively analyze CA at ng/ml level, and to extract CA's analogues from the sample matrix. Cheminformatics confirmed the presence of structural and functional similarity among these extracted compounds. This study offers a novel approach to preparing a readily synthesized extraction membrane capable of isolating compounds with structural and functional analogies, as well as developing a membrane solid-phase extraction-based analytical method for natural products.
(© 2024 John Wiley & Sons Ltd.)

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22376126 National Natural Science Foundation of China; 003083 Shandong First Medical University Key Talent Introduction Project; 2019LJ003 Academic Promotion Program of Shandong First Medical University

Keywords: Taraxaci Herba; caffeic acid; imidazolium ionic liquid; membrane extraction; microwave preparation; similarity of structure and function

0 (Caffeic Acids)
0 (Ionic Liquids)
0 (Imidazoles)
U2S3A33KVM (caffeic acid)
0 (Membranes, Artificial)
0 (Plant Extracts)

Date Created: 20240705 Date Completed: 20240816 Latest Revision: 20240816

20240816

10.1002/bmc.5953

38965739