Menu
×
John L. Dart Library
9 a.m. - 6 p.m.
Phone: (843) 722-7550
West Ashley Library
9 a.m. - 6 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 1 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 6 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 6 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 6 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 6 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 1 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 6 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 6 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 6 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. – 3 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 6 p.m.
Phone: (843) 552-6466
Baxter-Patrick James Island
9 a.m. - 6 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 6 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 6 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Today's Hours
John L. Dart Library
9 a.m. - 6 p.m.
Phone: (843) 722-7550
West Ashley Library
9 a.m. - 6 p.m.
Phone: (843) 766-6635
Folly Beach Library
9 a.m. - 1 p.m.
Phone: (843) 588-2001
Edgar Allan Poe/Sullivan's Island Library
Closed for renovations
Phone: (843) 883-3914
Wando Mount Pleasant Library
9 a.m. - 6 p.m.
Phone: (843) 805-6888
Village Library
9 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
9 a.m. - 6 p.m.
Phone: (843) 889-3300
Otranto Road Library
9 a.m. - 6 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
9 a.m. – 6 p.m.
Phone: (843) 849-6161
McClellanville Library
9 a.m. - 1 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
9 a.m. – 6 p.m.
Phone: (843) 744-2489
John's Island Library
9 a.m. - 6 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
9 a.m. - 6 p.m.
Phone: (843) 766-2546
Miss Jane's Building (Edisto Library Temporary Location)
9 a.m. – 3 p.m.
Phone: (843) 869-2355
Dorchester Road Library
9 a.m. - 6 p.m.
Phone: (843) 552-6466
Baxter-Patrick James Island
9 a.m. - 6 p.m.
Phone: (843) 795-6679
Main Library
9 a.m. - 6 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
9 a.m. - 6 p.m.
Phone: (843) 805-6892
Mobile Library
9 a.m. - 5 p.m.
Phone: (843) 805-6909
Patron Login
menu
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
Racial and ethnic disparities in gallbladder cancer: A two-decade analysis of incidence and mortality rates in the US.
Item request has been placed!
×
Item request cannot be made.
×
![loading](/sites/all/modules/hf_eds/images/loading.gif)
- Author(s): Abboud Y;Abboud Y; Singh L; Singh L; Fraser M; Fraser M; Pan CW; Pan CW; Abboud I; Abboud I; Mohamed IH; Mohamed IH; Kim D; Kim D; Alsakarneh S; Alsakarneh S; Jaber F; Jaber F; Richter B; Richter B; Al-Khazraji A; Al-Khazraji A; Hajifathalian K; Hajifathalian K; Vossough-Teehan S; Vossough-Teehan S
- Source:
Cancer medicine [Cancer Med] 2024 Jul; Vol. 13 (13), pp. e7457.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: John Wiley & Sons Ltd Country of Publication: United States NLM ID: 101595310 Publication Model: Print Cited Medium: Internet ISSN: 2045-7634 (Electronic) Linking ISSN: 20457634 NLM ISO Abbreviation: Cancer Med Subsets: MEDLINE
- Publication Information: Original Publication: [Malden, MA] : John Wiley & Sons Ltd., c2012-
- Subject Terms: Gallbladder Neoplasms*/mortality ; Gallbladder Neoplasms*/ethnology ; Gallbladder Neoplasms*/epidemiology ; Gallbladder Neoplasms*/pathology ; SEER Program*/statistics & numerical data ; Ethnicity*/statistics & numerical data; Humans ; United States/epidemiology ; Incidence ; Female ; Male ; Middle Aged ; Aged ; Health Status Disparities ; Adult ; Racial Groups/statistics & numerical data ; Neoplasm Staging ; Hispanic or Latino/statistics & numerical data ; Aged, 80 and over
- Abstract: Background: Gallbladder cancer (GBC) is an aggressive malignancy that is usually diagnosed at a late stage. Prior data showed increasing incidence of GBC in the US. However, little is known about race/ethnic-specific incidence and mortality trends of GBC per stage at diagnosis. Therefore, we aimed to conduct a time-trend analysis of GBC incidence and mortality rates categorized by race/ethnicity and stage-at-diagnosis.
Methods: Age-adjusted GBC incidence and mortality rates were calculated using SEER*Stat software from the United States Cancer Statistics database (covers ~98% of US population between 2001 and 2020) and NCHS (covers ~100% of the US population between 2000 and 2020) databases, respectively. Race/Ethnic groups were Non-Hispanic-White (NHW), Non-Hispanic-Black (NHB), Hispanic, Non-Hispanic-Asian/Pacific-Islander (NHAPI), and Non-Hispanic-American-Indian/Alaska-Native (NHAIAN). Stage-at-diagnoses were all stages, early, regional, and distant stages. Joinpoint regression was used to generate time-trends [annual percentage change (APC) and average APC (AAPC)] with parametric estimations and a two-sided t-test (p-value cut-off 0.05).
Results: 76,873 patients were diagnosed with GBC with decreasing incidence rates in all races/ethnicities except NHB who experienced an increasing trend between 2001 and 2014 (APC = 2.08, p < 0.01) and plateauing afterward (APC = -1.21, p = 0.31); (AAPC = 1.03, p = 0.03). Among early-stage tumors (9927 patients), incidence rates were decreasing only in Hispanic (AAPC = -4.24, p = 0.006) while stable in other races/ethnicities (NHW: AAPC = -2.61, p = 0.39; NHB: AAPC = -1.73, p = 0.36). For regional-stage tumors (29,690 patients), GBC incidence rates were decreasing only in NHW (AAPC = -1.61, p < 0.001) while stable in other races/ethnicities (NHB: AAPC = 0.73, p = 0.34; Hispanic: AAPC = -1.58, p = 0.24; NHAPI: AAPC = -1.22, p = 0.07). For distant-stage tumors (31,735 patients), incidence rates were increasing in NHB (AAPC = 2.72, p < 0.001), decreasing in Hispanic (AAPC = -0.64, p = 0.04), and stable in NHW (AAPC = 0.07, p = 0.84) and NHAPI (AAPC = 0.79, p = 0.13). There were 43,411 deaths attributed to GBC with decreasing mortality rates in all races/ethnicities except NHB who experienced a stable trend (AAPC = 0.25, p = 0.25).
Conclusion: Nationwide data over the last two decades show that NHB patients experienced increasing GBC incidence between 2001 and 2014 followed by stabilization of the rates. This increase was driven by late-stage tumors and occurred in the first decade. NHB also experienced non-improving GBC mortality, compared to other race and ethnic groups who had decreasing mortality. This can be due to lack of timely-access to healthcare leading to delayed diagnosis and worse outcomes. Future studies are warranted to investigate contributions to the revealed racial and ethnic disparities, especially in NHB, to improve early detection.
(© 2024 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd.) - References: Am J Gastroenterol. 2008 Sep;103(9):2301-7. (PMID: 18844616)
Hepatology. 2021 May;73(5):1783-1796. (PMID: 32893372)
Gastroenterol Clin North Am. 2010 Jun;39(2):307-30, ix. (PMID: 20478488)
J Gastrointest Surg. 2013 Nov;17(11):1897-906. (PMID: 24002757)
Am J Surg. 2022 Dec;224(6):1468-1472. (PMID: 36008169)
Heliyon. 2019 Nov 19;5(11):e02515. (PMID: 31768426)
J Gastrointest Oncol. 2018 Apr;9(2):348-353. (PMID: 29755774)
J Natl Cancer Inst. 1997 Aug 6;89(15):1132-8. (PMID: 9262251)
J Obes. 2013;2013:140743. (PMID: 23691282)
Stat Med. 2009 Dec 20;28(29):3670-82. (PMID: 19856324)
Chin Clin Oncol. 2019 Aug;8(4):31. (PMID: 31484487)
Curr Probl Cancer. 2012 Jul-Aug;36(4):216-24. (PMID: 22481009)
Cureus. 2016 Feb 12;8(2):e493. (PMID: 27014527)
Diabetes Metab Rev. 1990 Mar;6(2):71-90. (PMID: 2198151)
Cancer Med. 2017 Apr;6(4):874-880. (PMID: 28317286)
Cancer Med. 2013 Jun;2(3):403-11. (PMID: 23930216)
BMC Cancer. 2022 Nov 16;22(1):1178. (PMID: 36384474)
Clin Exp Hepatol. 2019 May;5(2):93-102. (PMID: 31501784)
Prostate Cancer Prostatic Dis. 2022 Sep;25(3):397-402. (PMID: 34475523)
Front Biosci (Landmark Ed). 2012 Jun 01;17(7):2550-8. (PMID: 22652797)
Eur J Cancer Prev. 2019 Jan;28(1):1-9. (PMID: 28683010) - Contributed Indexing: Keywords: disparities; gallbladder cancer; incidence; mortality; race
- Publication Date: Date Created: 20240704 Date Completed: 20240704 Latest Revision: 20240706
- Publication Date: 20240706
- Accession Number: PMC11222964
- Accession Number: 10.1002/cam4.7457
- Accession Number: 38963040
- Source:
Contact CCPL
Copyright 2022 Charleston County Public Library Powered By EBSCO Stacks 3.3.0 [350.3] | Staff Login
No Comments.