An evaluation of inflammatory and endothelial dysfunction markers as determinants of peripheral arterial disease in those with diabetes mellitus.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : Nature Publishing Group, copyright 2011-
    • Subject Terms:
    • Abstract:
      The most serious long-term effects of diabetes is peripheral artery disease (PAD) which increases the chance of developing diabetic foot ulcers, gangrene and even lower limb amputation. The clinical manifestations of PAD which are typically not revealed until symptoms like intermittent claudication, rest pain and ischemic gangrene develop, are not present in majority of diabetes mellitus patients with PAD due to diabetic peripheral neuropathy. Therefore, current study is aimed to evaluate the inflammatory and endothelial dysfunction markers with their correlation to biomarkers that can help for in-time diagnosis and efficient prognosis of developing diabetes-associated PAD. Enzyme-linked immunosorbent assay was used to evaluate the interlukin-6, interlukin-8, intercellular adhesion molecule (ICAM) and vascular cell adhesion molecule (VCAM) in PAD with diabetes group, diabetic group and healthy individual group while biomarkers were measured by kit method. It was observed that serum IL-6, IL-8, ICAM and VCAM levels in type II diabetes mellitus (T2DM) with PAD patients were increased significantly (85.93, 597.08, 94.80 and 80.66) as compared to T2DM patients (59.52, 231.34, 56.88 and 50.19) and healthy individuals (4.81, 16.93, 5.55 and 5.16). The overall means for the parameters, IL-6, IL-8, ICAM, VCAM, urea, S/creatinine, CK-MB, AST, ALT, cholesterol, triglyceride, HDL, LDL, PT, aPTT, INR, HbA1C, and CRP within all groups were significantly (P < 0.05) different from each other. Therefore, it was concluded that the change in IL-6, IL-8, ICAM and VCAM can serve as an accurate diagnostic indicator and successful treatment.
      (© 2024. The Author(s).)
    • References:
      Atherosclerosis. 2018 Sep;276:98-108. (PMID: 30055326)
      Am J Cardiol. 2011 May 1;107(9):1392-8. (PMID: 21371679)
      Atherosclerosis. 2004 Aug;175(2):361-7. (PMID: 15262193)
      Cardiovasc Diabetol. 2020 Jan 7;19(1):4. (PMID: 31910828)
      Cytokine Growth Factor Rev. 2010 Oct;21(5):331-44. (PMID: 21115385)
      Arch Biochem Biophys. 2020 May 15;684:108334. (PMID: 32173334)
      Heart. 2020 Jan;106(1):80-85. (PMID: 31843811)
      Spine (Phila Pa 1976). 2017 Dec 1;42(23):1817-1825. (PMID: 28538597)
      Vasa. 2019 Sep;48(Suppl 102):1-79. (PMID: 31789115)
      J Vasc Surg. 2015 Jan;61(1):155-61. (PMID: 25095746)
      World J Diabetes. 2010 May 15;1(2):48-56. (PMID: 21537427)
      Biosensors (Basel). 2018 Mar 30;8(2):. (PMID: 29601504)
      J Lipid Res. 2010 Nov;51(11):3364-9. (PMID: 20688754)
      Diabetes Metab Syndr. 2018 May;12(3):365-368. (PMID: 29310968)
      Nat Rev Endocrinol. 2018 Feb;14(2):88-98. (PMID: 29219149)
      Eur Heart J. 2007 Feb;28(3):354-62. (PMID: 17213229)
      Med Sci Monit. 2017 Oct 06;23:4789-4797. (PMID: 28983072)
      Diabetes Metab Syndr Obes. 2020 Oct 09;13:3611-3616. (PMID: 33116712)
      Bratisl Lek Listy. 2018;119(10):646-650. (PMID: 30345773)
      Eur Heart J. 2000 Oct;21(19):1614-20. (PMID: 10988014)
      Circulation. 2005 Aug 16;112(7):976-83. (PMID: 16087797)
      Curr Cardiol Rev. 2008 Aug;4(3):179-92. (PMID: 19936194)
      Int J Vasc Med. 2016;2016:6015701. (PMID: 27559483)
      Arterioscler Thromb Vasc Biol. 1999 Oct;19(10):2355-63. (PMID: 10521364)
      J Indian Soc Periodontol. 2013 Jan;17(1):30-5. (PMID: 23633769)
      Int Angiol. 2018 Aug;37(4):327-334. (PMID: 29936722)
      Am Fam Physician. 2019 Mar 15;99(6):362-369. (PMID: 30874413)
      Curr Atheroscler Rep. 2014 Jul;16(7):419. (PMID: 24781596)
      Cytokine. 2014 Nov;70(1):11-20. (PMID: 24986424)
      Circulation. 2017 Mar 21;135(12):e686-e725. (PMID: 27840332)
      Res Vet Sci. 2008 Aug;85(1):166-70. (PMID: 17998140)
      J Am Heart Assoc. 2018 Feb 2;7(3):. (PMID: 29420219)
      Arterioscler Thromb Vasc Biol. 1999 Jul;19(7):1623-9. (PMID: 10397679)
      Intern Emerg Med. 2010 Feb;5(1):13-25. (PMID: 19626421)
      Hematol Transfus Cell Ther. 2019 Jan-Mar;41(1):31-36. (PMID: 30793102)
      Int J Mol Sci. 2021 Mar 30;22(7):. (PMID: 33808453)
      Indian J Hematol Blood Transfus. 2012 Jun;28(2):105-8. (PMID: 23730017)
      Int J Mol Med. 2014 Apr;33(4):777-83. (PMID: 24535646)
      Atherosclerosis. 2005 Dec;183(2):301-7. (PMID: 16285993)
      Lancet. 2013 Oct 19;382(9901):1329-40. (PMID: 23915883)
      Heart Vessels. 2019 Jun;34(6):976-983. (PMID: 30535754)
      Minerva Med. 2018 Dec;109(6):443-450. (PMID: 29652038)
      Clin Chim Acta. 2015 Jul 20;447:16-22. (PMID: 25979692)
      J Am Coll Cardiol. 2005 Sep 20;46(6):1112-3. (PMID: 16168299)
      J Vasc Surg. 2018 Jan;67(1):217-228.e1. (PMID: 28844470)
      J Clin Invest. 2003 Jun;111(12):1805-12. (PMID: 12813013)
      Clin Hemorheol Microcirc. 2001;25(2):49-53. (PMID: 11790870)
      Hypertension. 1997 Jan;29(1 Pt 2):366-73. (PMID: 9039129)
      Int J Environ Res Public Health. 2022 Aug 09;19(16):. (PMID: 36011445)
      Ther Adv Endocrinol Metab. 2021 Mar 09;12:20420188211000504. (PMID: 33767809)
      Pak J Med Sci. 2016 Jul-Aug;32(4):955-60. (PMID: 27648047)
      Diabetologia. 2002 Feb;45(2):210-6. (PMID: 11935152)
      Front Immunol. 2018 Mar 02;9:430. (PMID: 29552019)
      Angiology. 2016 Oct;67(9):870-4. (PMID: 26888895)
      Cureus. 2018 Nov 23;10(11):e3626. (PMID: 30697502)
      Diagnostics (Basel). 2020 May 16;10(5):. (PMID: 32429406)
      Diabetes Care. 2018 Sep;41(9):2045-2047. (PMID: 30135199)
      Biomark Med. 2019 Apr;13(6):467-478. (PMID: 31169028)
      Vasc Med. 2009 Nov;14(4):381-92. (PMID: 19808725)
      Curr Diabetes Rev. 2013 Jan 1;9(1):25-53. (PMID: 22974359)
      Vascular. 2017 Apr;25(2):208-224. (PMID: 27411571)
      Am J Cardiol. 2005 Nov 15;96(10):1374-8. (PMID: 16275181)
      Int J Cardiol. 2013 Oct 15;168(6):5126-34. (PMID: 23978367)
      Clin Chem. 2017 Jan;63(1):236-244. (PMID: 27872083)
      Int J Environ Res Public Health. 2018 Sep 06;15(9):. (PMID: 30200612)
      Adv Immunol. 1993;54:1-78. (PMID: 8379461)
      Vasc Med. 2003;8(1):15-9. (PMID: 12866607)
      Nat Rev Cardiol. 2019 Jul;16(7):389-406. (PMID: 30846875)
      J Diabetes. 2017 Feb;9(2):133-140. (PMID: 27556728)
      J Cardiovasc Pharmacol. 2009 Dec;54(6):520-5. (PMID: 19755917)
      Medicine (Baltimore). 2015 Jun;94(24):e948. (PMID: 26091458)
      J Extracell Vesicles. 2020 Feb 19;9(1):1729646. (PMID: 32158521)
      J Zhejiang Univ Sci B. 2015 May;16(5):355-61. (PMID: 25990052)
      Eur J Vasc Endovasc Surg. 2017 Aug;54(2):220-233. (PMID: 28666785)
      Arterioscler Thromb Vasc Biol. 2020 Sep;40(9):2018-2032. (PMID: 32640905)
      J Med Biochem. 2015 Apr;34(2):179-190. (PMID: 28356830)
      Eur Respir J. 2006 Jul;28(1):219-42. (PMID: 16816350)
      Oxid Med Cell Longev. 2019 Jul 1;2019:8563845. (PMID: 31354915)
      J Clin Lab Anal. 2012 May;26(3):206-14. (PMID: 22628238)
      Diagnostics (Basel). 2020 Sep 20;10(9):. (PMID: 32962217)
      Thromb Res. 2006;117(4):357-64. (PMID: 15890391)
      Eur J Vasc Endovasc Surg. 2005 Feb;29(2):171-6. (PMID: 15649725)
    • Contributed Indexing:
      Keywords: Interleukin-6; Interleukin-8; Peripheral arterial disease; Type 2 diabetes mellitus; Vascular cell adhesion molecule
    • Accession Number:
      0 (Biomarkers)
      0 (Vascular Cell Adhesion Molecule-1)
      0 (Interleukin-6)
      126547-89-5 (Intercellular Adhesion Molecule-1)
      0 (Interleukin-8)
    • Publication Date:
      Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240706
    • Publication Date:
      20240706
    • Accession Number:
      PMC11222457
    • Accession Number:
      10.1038/s41598-024-65188-w
    • Accession Number:
      38961103