Acute intravascular haemolysis associated with scrub typhus.

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  • Additional Information
    • Source:
      Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE
    • Publication Information:
      Original Publication: London : BMJ Pub. Group
    • Subject Terms:
      Scrub Typhus*/complications ; Scrub Typhus*/diagnosis ; Scrub Typhus*/drug therapy ; Doxycycline*/therapeutic use ; Anti-Bacterial Agents*/therapeutic use; Humans ; Male ; Anemia, Hemolytic/etiology ; Anemia, Hemolytic/diagnosis ; Adult ; Orientia tsutsugamushi/isolation & purification
    • Abstract:
      Scrub typhus, a prevalent tropical infection, may sometimes manifest with unusual complications. Here, we present the case of a young man who was admitted to our facility with a fever for the past 3 days and passage of dark-coloured urine since that morning. On investigation, we identified intravascular haemolytic anaemia. Through meticulous examination, a black necrotic lesion (eschar) was discovered on his right buttock, a pathognomonic sign of scrub typhus infection. Treatment was initiated with oral doxycycline 100 mg two times a day. Subsequently, diagnosis of scrub typhus was confirmed through positive results from scrub typhus IgM via ELISA and PCR analysis from the eschar tissue. The patient responded well to oral doxycycline and his symptoms resolved within the next few days. This case highlights severe intravascular haemolysis associated with scrub typhus infection.
      Competing Interests: Competing interests: None declared.
      (© BMJ Publishing Group Limited 2024. No commercial re-use. See rights and permissions. Published by BMJ.)
    • Contributed Indexing:
      Keywords: Doxycycline; General practice / family medicine; Haematology (incl blood transfusion); Tropical medicine (infectious disease)
    • Accession Number:
      N12000U13O (Doxycycline)
      0 (Anti-Bacterial Agents)
    • Publication Date:
      Date Created: 20240703 Date Completed: 20240703 Latest Revision: 20240703
    • Publication Date:
      20240704
    • Accession Number:
      10.1136/bcr-2024-261003
    • Accession Number:
      38960428