Research progress of propofol in alleviating cerebral ischemia/reperfusion injury.

Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101234999 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2299-5684 (Electronic) Linking ISSN: 17341140 NLM ISO Abbreviation: Pharmacol Rep Subsets: MEDLINE

Publication: 2020- : Cham, Switzerland : Springer International Publishing
Original Publication: Kraków, Poland : Institute of Pharmacology, Polish Academy of Sciences, c2005-

Propofol*/pharmacology ; Propofol*/therapeutic use ; Reperfusion Injury*/drug therapy ; Reperfusion Injury*/metabolism ; Neuroprotective Agents*/pharmacology ; Neuroprotective Agents*/therapeutic use ; Brain Ischemia*/drug therapy ; Brain Ischemia*/metabolism; Humans ; Animals ; Oxidative Stress/drug effects ; Anesthetics, Intravenous/pharmacology ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/therapeutic use

Ischemic stroke is a leading cause of adult disability and death worldwide. The primary treatment for cerebral ischemia patients is to restore blood supply to the ischemic region as quickly as possible. However, in most cases, more severe tissue damage occurs, which is known as cerebral ischemia/reperfusion (I/R) injury. The pathological mechanisms of brain I/R injury include mitochondrial dysfunction, oxidative stress, excitotoxicity, calcium overload, neuroinflammation, programmed cell death and others. Propofol (2,6-diisopropylphenol), a short-acting intravenous anesthetic, possesses not only sedative and hypnotic effects but also immunomodulatory and neuroprotective effects. Numerous studies have reported the protective properties of propofol during brain I/R injury. In this review, we summarize the potential protective mechanisms of propofol to provide insights for its better clinical application in alleviating cerebral I/R injury.
(© 2024. The Author(s) under exclusive licence to Maj Institute of Pharmacology Polish Academy of Sciences.)

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222102310566 Henan Provincial Science and Technology Research Project; XYBSKYZZ201810 Xinxiang Medical University

Keywords: Cerebral ischemia/reperfusion injury; Neuroinflammation; Programmed cell death; Propofol

YI7VU623SF (Propofol)
0 (Neuroprotective Agents)
0 (Anesthetics, Intravenous)
0 (Hypnotics and Sedatives)

Date Created: 20240702 Date Completed: 20240910 Latest Revision: 20240910

20240911

10.1007/s43440-024-00620-6

38954373