New device for assessment of endothelial function: plethysmographic flow-mediated vasodilation (pFMD).

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 9307690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1348-4214 (Electronic) Linking ISSN: 09169636 NLM ISO Abbreviation: Hypertens Res Subsets: MEDLINE
    • Publication Information:
      Publication: 2009- : London : Nature Publishing Group
      Original Publication: Toyonaka, Japan : The Society, c1992-2003
    • Subject Terms:
      Vasodilation*/physiology ; Endothelium, Vascular*/physiology ; Brachial Artery*/physiology ; Plethysmography*/methods; Humans ; Male ; Adult ; Cross-Sectional Studies ; Middle Aged ; Hyperemia/physiopathology ; Ultrasonography
    • Abstract:
      Measurement of flow-mediated vasodilation (FMD) in the brachial artery by using ultrasound is a well-established technique for evaluating endothelial function. To make the measurement quicker and simpler than the measurements of conventional ultrasound FMD (uFMD), we have developed a new noninvasive method, plethysmographic FMD (pFMD), to assess vascular response to reactive hyperemia in the brachial artery. The aim of this study was to determine the accuracy of measurement of pFMD in comparison to that of measurement of conventional uFMD. This study was a multi-center, cross-sectional study. We compared pFMD by a new device using cuff pressure and volume with conventional uFMD using ultrasound in 50 men (mean age, 41 ± 9 years). pFMD significantly correlated with conventional uFMD (β = 0.59, P < 0.001). In Bland-Altman plot analysis of pFMD and conventional uFMD, the mean difference of pFMD and conventional uFMD was 0.78%, and limits of agreement (mean difference ±2 standard deviations of the difference) ranged from -4.53% to 6.11%. We demonstrated validity of the new method for measurement of pFMD, which can automate the evaluation of endothelial function in a short time. Measurement of pFMD is simpler than measurement of conventional uFMD and may have reduced artificial bias compared to that of conventional uFMD measurement (URL for Clinical Trial: https://ethics.hiroshima-u.ac.jp/site/wp-content/uploads/2022/12/eki_giji20221213.pdf . Registration Number for Clinical Trial: E2022-0131).
      (© 2024. The Author(s).)
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    • Contributed Indexing:
      Keywords: Endothelial function; Flow-mediated vasodilation; Plethysmographic flow-mediated vasodilation
    • Publication Date:
      Date Created: 20240701 Date Completed: 20240904 Latest Revision: 20241122
    • Publication Date:
      20241122
    • Accession Number:
      PMC11374665
    • Accession Number:
      10.1038/s41440-024-01770-z
    • Accession Number:
      38951680