[Effect of Intrauterine Perfusion of Granulocyte Colony-Stimulating Factor on Endometrium and Blood Flow Parameters in Patients With Thin Endometrium: A Prospective Controlled Clinical Trial].

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  • Additional Information
    • Transliterated Title:
      宫腔灌注粒细胞集落刺激因子改善薄型子宫内膜患者内膜及血流参数的前瞻性临床对照试验.
    • Source:
      Publisher: Sichuan da xue xue bao (yi xue ban) bian ji bu Country of Publication: China NLM ID: 101162609 Publication Model: Print Cited Medium: Print ISSN: 1672-173X (Print) Linking ISSN: 1672173X NLM ISO Abbreviation: Sichuan Da Xue Xue Bao Yi Xue Ban Subsets: MEDLINE
    • Publication Information:
      Original Publication: Chengdu Shi : Sichuan da xue xue bao (yi xue ban) bian ji bu, 2003-
    • Subject Terms:
      Endometrium*/blood supply ; Granulocyte Colony-Stimulating Factor*/administration & dosage ; Granulocyte Colony-Stimulating Factor*/therapeutic use ; Granulocyte Colony-Stimulating Factor*/pharmacology ; Embryo Transfer*/methods ; Pregnancy Rate*; Humans ; Female ; Prospective Studies ; Pregnancy ; Adult ; Perfusion
    • Abstract:
      Objective: To investigate the effects of intrauterine perfusion with granulocyte colony-stimulating factor (G-CSF) on the endometrial thickness, volume, and blood flow parameters of patients with thin endometrium and their clinical outcomes.
      Methods: We designed a prospective non-randomized synchronous controlled trial and recruited patients with thin endometrium who underwent frozen-thawed embryo transfer (FET) at Mianyang Central Hospital between September 1, 2021 and September 1, 2023. They were divided into two groups, an experimental group of patients who received the experimental treatment of intrauterine perfusion with G-CSF and a control group of patients who did not receive the experimental treatment. The general data and the clinical outcomes of the two groups were analyzed and compared. The endometrial thickness, volume and blood flow parameters of patients in the experimental group before and after intrauterine perfusion with G-CSF were analyzed.
      Results: The clinical data of 83 patients were included in the study. The experimental group included 51 cases, while the control group included 31 cases. There were no significant differences in the baseline data between the two groups. The clinical pregnancy rate of the experimental group (56.86%) was higher than that of the control group (50.00%) and the rate of spontaneous abortion in the experimental group (27.59%) was lower than that in the control group (37.50%), but the differences were not statistically significant ( P >0.05). In the experimental group, the postperfusion endometrial thickness ([0.67±0.1] cm) was greater than the preperfusion endometrial thickness ([0.59±0.09] cm), the postperfusion ([1.84±0.81] cm 3 ) was greater than the preperfusion endometrial volume ([1.54±0.69] cm 3 ), and the postperfusion vascularization flow index (VFI) (1.97±2.82) was greater than the preperfusion VFI (0.99±1.04), with all the differences being statistically significant ( P <0.05).
      Conclusion: Intrauterine perfusion with G-CSF can enhance the endometrial thickness, volume, and some blood flow parameters in patients with thin endometrium.
      Competing Interests: 利益冲突　所有作者均声明不存在利益冲突
      (© 2024《四川大学学报（医学版）》编辑部 版权所有Copyright ©2024 Editorial Office of Journal of Sichuan University (Medical Sciences).)
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    • Contributed Indexing:
      Keywords: Endometrial receptivity; Granulocyte colony-stimulating factor; Intrauterine perfusion; Thin endometrium
    • Accession Number:
      143011-72-7 (Granulocyte Colony-Stimulating Factor)
    • Publication Date:
      Date Created: 20240701 Date Completed: 20240701 Latest Revision: 20241010
    • Publication Date:
      20241010
    • Accession Number:
      PMC11211764
    • Accession Number:
      10.12182/20240560504
    • Accession Number:
      38948297