Oxidative Stress-Associated Male Infertility: Current Diagnostic and Therapeutic Approaches.

Publisher: MDPI Country of Publication: Switzerland NLM ID: 9425208 Publication Model: Electronic Cited Medium: Internet ISSN: 1648-9144 (Electronic) Linking ISSN: 1010660X NLM ISO Abbreviation: Medicina (Kaunas) Subsets: MEDLINE

Publication: 2018- : Basel, Switzerland : MDPI
Original Publication: Kaunas : Lietuvos gydytojų sąjunga

Oxidative Stress*/physiology ; Infertility, Male*/etiology ; Infertility, Male*/diagnosis ; Infertility, Male*/therapy ; Antioxidants*/therapeutic use; Humans ; Male ; Reactive Oxygen Species/metabolism ; Spermatozoa/metabolism ; Spermatozoa/physiology

Infertility is a prevalent global issue affecting approximately 17.5% of adults, with sole male factor contributing to 20-30% of cases. Oxidative stress (OS) is a critical factor in male infertility, disrupting the balance between reactive oxygen species (ROS) and antioxidants. This imbalance detrimentally affects sperm function and viability, ultimately impairing fertility. OS also triggers molecular changes in sperm, including DNA damage, lipid peroxidation, and alterations in protein expression, further compromising sperm functionality and potential fertilization. Diagnostic tools discussed in this review offer insights into OS markers, antioxidant levels, and intracellular ROS concentrations. By accurately assessing these parameters, clinicians can diagnose male infertility more effectively and thus tailor treatment plans to individual patients. Additionally, this review explores various treatment options for males with OS-associated infertility, such as empirical drugs, antioxidants, nanoantioxidants, and lifestyle modifications. By addressing the root causes of male infertility and implementing targeted interventions, clinicians can optimize treatment outcomes and enhance the chances of conception for couples struggling with infertility.

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Keywords: antioxidants; male infertility; oxidative stress; reactive oxygen species

0 (Antioxidants)
0 (Reactive Oxygen Species)

Date Created: 20240627 Date Completed: 20240627 Latest Revision: 20240629

20240629

PMC11205999

10.3390/medicina60061008

38929625