A multifaceted kinase axis regulates plant organ abscission through conserved signaling mechanisms.

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  • Additional Information
    • Source:
      Publisher: Cell Press Country of Publication: England NLM ID: 9107782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0445 (Electronic) Linking ISSN: 09609822 NLM ISO Abbreviation: Curr Biol Subsets: MEDLINE
    • Publication Information:
      Publication: Cambridge, MA : Cell Press
      Original Publication: London, UK : Current Biology Ltd., c1991-
    • Subject Terms:
      Arabidopsis*/genetics ; Arabidopsis*/growth & development ; Arabidopsis*/physiology ; Arabidopsis*/metabolism ; Arabidopsis Proteins*/metabolism ; Arabidopsis Proteins*/genetics ; Signal Transduction* ; Flowers*/growth & development ; Flowers*/genetics; Gene Expression Regulation, Plant ; Protein Serine-Threonine Kinases/metabolism ; Protein Serine-Threonine Kinases/genetics ; Protein Kinases/metabolism ; Protein Kinases/genetics
    • Abstract:
      Plants have evolved mechanisms to abscise organs as they develop or when exposed to unfavorable conditions. 1 Uncontrolled abscission of petals, fruits, or leaves can impair agricultural productivity. 2 , 3 , 4 , 5 Despite its importance for abscission progression, our understanding of the IDA signaling pathway and its regulation remains incomplete. IDA is secreted to the apoplast, where it is perceived by the receptors HAESA (HAE) and HAESA-LIKE2 (HSL2) and somatic embryogenesis receptor kinase (SERK) co-receptors. 6 , 7 , 8 , 9 These plasma membrane receptors activate an intracellular cascade of mitogen-activated protein kinases (MAPKs) by an unknown mechanism. 10 , 11 , 12 Here, we characterize brassinosteroid signaling kinases (BSKs) as regulators of floral organ abscission in Arabidopsis. BSK1 localizes to the plasma membrane of abscission zone cells, where it interacts with HAESA receptors to regulate abscission. Furthermore, we demonstrate that YODA (YDA) has a leading role among other MAPKKKs in controlling abscission downstream of the HAESA/BSK complex. This kinase axis, comprising a leucine-rich repeat receptor kinase, a BSK, and an MAPKKK, is known to regulate stomatal patterning, early embryo development, and immunity. 10 , 13 , 14 , 15 , 16 How specific cellular responses are obtained despite signaling through common effectors is not well understood. We show that the identified abscission-promoting allele of BSK1 also enhances receptor signaling in other BSK-mediated pathways, suggesting conservation of signaling mechanisms. Furthermore, we provide genetic evidence supporting independence of BSK1 function from its kinase activity in several developmental processes. Together, our findings suggest that BSK1 facilitates signaling between plasma membrane receptor kinases and MAPKKKs via conserved mechanisms across multiple facets of plant development.
      Competing Interests: Declaration of interests The authors declare no competing interests.
      (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: BSK; IDA; MAPKKK; YDA; abscission; receptor kinase; signaling
    • Accession Number:
      0 (Arabidopsis Proteins)
      EC 2.7.11.1 (Protein Serine-Threonine Kinases)
      EC 2.7.- (Protein Kinases)
    • Publication Date:
      Date Created: 20240625 Date Completed: 20240709 Latest Revision: 20240710
    • Publication Date:
      20240711
    • Accession Number:
      10.1016/j.cub.2024.05.057
    • Accession Number:
      38917797