Advantageous early-life environments cushion the genetic risk for ischemic heart disease.

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  • Additional Information
    • Source:
      Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : National Academy of Sciences
    • Subject Terms:
      Myocardial Ischemia*/genetics ; Myocardial Ischemia*/mortality ; Genetic Predisposition to Disease* ; Infant Mortality*; Humans ; Female ; Male ; Infant ; United Kingdom/epidemiology ; Risk Factors ; Middle Aged ; Infant, Newborn ; Aged ; Adult
    • Abstract:
      In one of the first papers on the impact of early-life conditions on individuals' health in older age, Barker and Osmond [ Lancet , 327 , 1077-1081 (1986)] show a strong positive relationship between infant mortality rates in the 1920s and ischemic heart disease in the 1970s. We merge historical data on infant mortality rates to 370,000 individual records in the UK Biobank using information on local area and year of birth. We replicate the association between the early-life infant mortality rate and later-life ischemic heart disease in our sample. We then go "beyond Barker," by showing considerable genetic heterogeneity in this association that is robust to within-area as well as within-family analyses. We find no association between the polygenic index and heart disease in areas with the lowest infant mortality rates, but a strong positive relationship in areas characterized by high infant mortality. These findings suggest that advantageous environments can cushion one's genetic disease risk.
      Competing Interests: Competing interests statement:The authors declare no competing interest.
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    • Grant Information:
      462-16-100 EC | Horizon 2020 Framework Programme (H2020); 851725 EC | ERC | HORIZON EUROPE European Research Council (ERC); MR/N0137941/1 UKRI | Medical Research Council (MRC)
    • Contributed Indexing:
      Keywords: Barker hypothesis; ESSGN; developmental origins; gene–environment interplay
    • Publication Date:
      Date Created: 20240625 Date Completed: 20240625 Latest Revision: 20240710
    • Publication Date:
      20240710
    • Accession Number:
      PMC11228495
    • Accession Number:
      10.1073/pnas.2314056121
    • Accession Number:
      38917008