Choledochoscopy combined with double-cannula lavage in the treatment of acute pancreatitis with encapsulated necrosis and the analysis of related inflammatory indexes.

Publisher: Springer Country of Publication: Germany NLM ID: 8806653 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2218 (Electronic) Linking ISSN: 09302794 NLM ISO Abbreviation: Surg Endosc Subsets: MEDLINE

Publication: 1992- : New York : Springer
Original Publication: [Berlin] : Springer International, c1987-

Therapeutic Irrigation*/methods ; Pancreatitis, Acute Necrotizing*/surgery ; Pancreatitis, Acute Necrotizing*/blood; Humans ; Female ; Male ; Middle Aged ; Adult ; C-Reactive Protein/analysis ; Aged ; Endoscopy, Digestive System/methods ; Leukocyte Count ; Procalcitonin/blood

Objective: This study aimed to evaluate the application of choledochoscopy combined with double-cannula lavage in the treatment of acute pancreatitis (AP) with encapsulated necrosis and analyzed related inflammatory indexes.
Methods: Thirty patients with AP with encapsulated necrosis were enrolled and treated with choledochoscopy and double-cannula lavage. Serum white blood cell (WBC), procalcitonin (PCT), C-reactive protein (CRP), interleukin 6 (IL-6), IL-8, tumor necrosis factor alpha (TNF-α), and related inflammatory indexes were detected before and after surgery.
Results: All of the participants who underwent the surgery recovered well and were discharged without serious complications; no deaths occurred. The serum WBC, PCT, and CRP of patients after surgery decreased compared with before the procedure, and the differences in WBC and CRP were statistically significant (P < 0.05); the difference in PCT was not statistically significant (P > 0.05). Postoperatively, IL-6, IL-8, and TNF-α levels were higher than before surgery, and the differences were statistically significant (P < 0.05).
Conclusion: The surgical method presented herein effectively controlled and alleviated the infection of patients; it also did not increase the risk of infection and can thus be considered a safe and effective surgical method.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)

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Z181100001718087 Beijing Municipal Science and Technology Project

Keywords: Acute pancreatitis; Choledochoscopy; Inflammatory factor; Pancreatic encapsulated necrosis

9007-41-4 (C-Reactive Protein)
0 (Procalcitonin)

Date Created: 20240624 Date Completed: 20240730 Latest Revision: 20240730

20240731

10.1007/s00464-024-10997-3

38914886