Synthesis and Biological Evaluation of Benzamide Compounds as Insecticides Agents Against Spodoptera Frugiperda (Lepidoptera: Noctuidae).

Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE

Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-

Benzamides*/pharmacology ; Benzamides*/chemical synthesis ; Benzamides*/chemistry ; Insecticides*/pharmacology ; Insecticides*/chemistry ; Insecticides*/chemical synthesis ; Spodoptera*/drug effects ; Larva*/drug effects; Animals ; Structure-Activity Relationship ; Molecular Structure ; Dose-Response Relationship, Drug

Due to its severe damage, Spodoptera frugiperda is receiving attention as one of the biggest dangers to world food security. Although there are numerous insecticides that are widely and successfully used to control S. frugiperda, they do not have an immediate effect. In our work focusing for synthesized twelve novel benzamide derivatives and examined their insecticidal effectiveness against S. frugiperda larvae in their second & fourth larvae instars, with the aim of further improving the insecticidal activity based on combination principles. Several spectroscopic methods, including elemental analysis, NMR & infrared spectroscopy, were employed for confirming the structure of the newly designed products. It has been discovered that most compounds show good of promising efficacy. With an LC 50 of 24.8 mg/L for larvae in the second instar & 56.2 mg/L for larvae in the fourth instar, compound 23 was the most active. Among all compounds 11, 22 and 20 exhibited excellent results. Furthermore, a number of biological and histopathological properties of the demonstration compounds of the produced goods under laboratory conditions were also examined. This work further demonstrates the anti-proliferation of S. frugiperda and offers fresh ideas for the manufacture of benzamide derivatives.
(© 2024 Wiley-VHCA AG, Zurich, Switzerland.)

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Deanship of Scientific Research, Vice Presidency for Graduate Studies; GRANT A084 Scientific Research at King Faisal University, Saudi Arabia

Keywords: Insecticidal activity; Spodoptera Frugiperda; Toxicity; biological aspects; bnzamide

0 (Benzamides)
0 (Insecticides)
6X80438640 (benzamide)

Date Created: 20240620 Date Completed: 20240821 Latest Revision: 20240821

20240821

10.1002/cbdv.202400948

38899798