Oral Administration of Deer Bone Collagen Peptide Can Enhance the Skin Hydration Ability and Antioxidant Ability of Aging Mice Induced by D-Gal, and Regulate the Synthesis and Degradation of Collagen.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Deer* ; Antioxidants*/pharmacology ; Skin*/metabolism ; Skin*/drug effects ; Bone and Bones*/drug effects ; Bone and Bones*/metabolism ; Collagen*/metabolism ; Aging*/drug effects; Animals ; Mice ; Administration, Oral ; Peptides/pharmacology ; Skin Aging/drug effects ; Male ; Fermentation ; Collagen Type I/metabolism

Skin problems caused by aging have attracted much attention, and marine collagen peptides have been proved to improve these problems, while mammalian collagen peptides are rarely reported. In this study, fermented deer bone collagen peptide (FCP) and non-fermented deer bone collagen peptide (NCP) were extracted from fermented and non-fermented deer bone, respectively, and their peptide sequences and differential proteins were analyzed using LC-MS/MS technology. After they were applied to aging mice induced with D-gal, the skin hydration ability, antioxidant ability, collagen synthesis, and degradation ability of the mice were studied. The results show that FCP and NCP are mainly peptides that constitute type Ⅰ collagen, and their peptide segments are different. In vivo experiments show that FCP and NCP can improve the richness of collagen fibers in the skin of aging mice; improve the hydration ability of skin; promote the activity of antioxidant-related enzymes; and also show that through the TGF-β and MAPK pathways, the synthesis and degradation of collagen in skin are regulated. These results show that deer bone collagen peptide can improve skin problems caused by aging, promote skin hydration and antioxidant capacity of aging mice, and regulate collagen synthesis and degradation through the MAPK pathway.

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20220304001YY Major Science and Technology Projects in Jilin Province; 20220304003YY Major Science and Technology Projects in Jilin Province

Keywords: antioxidation; collagen peptide; deer bone; hydration; synthesis and degradation of collagen

0 (Antioxidants)
9007-34-5 (Collagen)
0 (Peptides)
0 (Collagen Type I)

Date Created: 20240619 Date Completed: 20240619 Latest Revision: 20240703

20240703

PMC11174718

10.3390/nu16111548

38892482