Increased frequency of microalbuminuria in patients with type 3 autoimmune polyglandular syndrome (APS) compared to isolated autoimmune type 1 diabetes mellitus: A real-life study.

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  • Additional Information
    • Source:
      Publisher: Elsevier Scientific Publishers Country of Publication: Ireland NLM ID: 8508335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8227 (Electronic) Linking ISSN: 01688227 NLM ISO Abbreviation: Diabetes Res Clin Pract Subsets: MEDLINE
    • Publication Information:
      Publication: 1993- : Limerick : Elsevier Scientific Publishers
      Original Publication: Amsterdam : Elsevier Science Publishers B.V., c1985-
    • Subject Terms:
      Diabetes Mellitus, Type 1*/complications ; Diabetes Mellitus, Type 1*/drug therapy ; Polyendocrinopathies, Autoimmune*/complications ; Polyendocrinopathies, Autoimmune*/drug therapy ; Albuminuria* ; Thyroxine*/therapeutic use; Humans ; Female ; Male ; Retrospective Studies ; Adult ; Middle Aged ; Age of Onset ; Young Adult ; Adolescent ; Glycated Hemoglobin/metabolism ; Glycated Hemoglobin/analysis
    • Abstract:
      Aim of the Study: The primary aim of the study was to evaluate the differences in metabolic control and chronic microvascular complications in patients with type 3 autoimmune polyglandular syndrome (APS3), compared to type 1 diabetes mellitus (T1DM) alone. Secondary aims were to evaluate the age of autoimmune thyroid disease (AIT) onset and the effects of levothyroxine treatment on metabolic control in patients with APS3.
      Material and Methods: We retrospectively reviewed 276 patients with T1DM alone and 214 patients with APS3 and evaluated clinical and metabolic parameters and microvascular complications.
      Results: Patients with T1DM showed a longer duration of diabetes (p = 0.001) and lower age of diabetes onset (p = 0.020) compared to patients with APS3. Female gender (p = 0.001) and microalbuminuria (p = 0.006) were significantly more frequent in patients with APS3 compared to T1DM. In addition, patients with APS3 showed higher AIT onset frequency in the 16-30 quartile age-range. Furthermore, APS3 patients treated with levothyroxine showed significantly better HbA1c values than non-treated patients (p = 0.001).
      Conclusions: We found that patients with APS3 showed positive microalbuminuria, earlier than T1DM. Patients with APS3 showed higher frequency of AIT age of onset in the 16-30 age-range and those treated with levothyroxine had better metabolic control, than untreated ones.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Autoimmune thyroid disease; Diabetic nephropathy; Hashimoto thyroiditis; Levothyroxine treatment; Metabolic control
    • Accession Number:
      Q51BO43MG4 (Thyroxine)
      0 (Glycated Hemoglobin)
    • Publication Date:
      Date Created: 20240617 Date Completed: 20240712 Latest Revision: 20240712
    • Publication Date:
      20240713
    • Accession Number:
      10.1016/j.diabres.2024.111746
    • Accession Number:
      38885744