3D printing of fish-scale derived hydroxyapatite/chitosan/PCL scaffold for bone tissue engineering.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier
      Original Publication: Guildford, Eng., IPC Science and Technology Press.
    • Subject Terms:
      Chitosan*/chemistry ; Durapatite*/chemistry ; Tissue Engineering*/methods ; Tissue Scaffolds*/chemistry ; Printing, Three-Dimensional* ; Polyesters*/chemistry; Animals ; Bone and Bones/drug effects ; Bone Regeneration/drug effects ; Animal Scales/chemistry ; Fishes ; Biocompatible Materials/chemistry ; Biocompatible Materials/pharmacology ; Spectroscopy, Fourier Transform Infrared
    • Abstract:
      In the field of bone tissue repair, the treatment of bone defects has always posed a significant challenge. In recent years, the advancement of bone tissue engineering and regenerative medicine has sparked great interest in the development of innovative bone grafting materials. In this study, a novel hydroxyapatite (HA) material was successfully prepared and comprehensively characterized. Antimicrobial experiments and biological evaluations were conducted to determine its efficacy. Based on the aforementioned research findings, 3D printing technology was employed to fabricate HA/chitosan (CS)/ polycaprolactone (PCL) scaffolds. The composition of the scaffold materials was confirmed through X-ray diffractometer (XRD) and Fourier Transform Infrared Spectroscopy (FT-IR) tests, while the influence of different HA ratios on the scaffold surface morphology was observed. Additionally, antimicrobial experiments demonstrated the favorable antimicrobial activity of the scaffolds containing 30%HA + 5%CS + PCL. Furthermore, the water contact angle measurements confirmed the superhydrophilicity of the scaffolds. Finally, the excellent bioactivity and ability to promote tissue regeneration of the scaffolds were further confirmed by in vitro and in vivo experiments. This study provides new options for future repair and regeneration of bone tissue and clinical applications.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported herein.
      (Copyright © 2024 Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Bone tissue repair; Chitosan; Hydroxyapatite
    • Accession Number:
      9012-76-4 (Chitosan)
      91D9GV0Z28 (Durapatite)
      24980-41-4 (polycaprolactone)
      0 (Polyesters)
      0 (Biocompatible Materials)
    • Publication Date:
      Date Created: 20240616 Date Completed: 20240730 Latest Revision: 20240730
    • Publication Date:
      20240730
    • Accession Number:
      10.1016/j.ijbiomac.2024.133172
    • Accession Number:
      38880458