Asthma control associated with anxiety and depression in asthmatic children following post-acute COVID-19.

Publisher: Blackwell Publishing Country of Publication: England NLM ID: 9106718 Publication Model: Print Cited Medium: Internet ISSN: 1399-3038 (Electronic) Linking ISSN: 09056157 NLM ISO Abbreviation: Pediatr Allergy Immunol Subsets: MEDLINE

Publication: <2010->: Oxford, UK : Blackwell Publishing
Original Publication: Copenhagen : Munksgaard, c1990-

COVID-19*/psychology ; COVID-19*/complications ; COVID-19*/epidemiology ; Asthma*/epidemiology ; Asthma*/psychology ; Depression*/epidemiology ; Depression*/etiology ; Anxiety*/epidemiology ; Anxiety*/etiology ; SARS-CoV-2*; Humans ; Child ; Male ; Female ; Adolescent ; Prospective Studies ; Case-Control Studies ; Nitric Oxide/analysis ; Nitric Oxide/metabolism ; Spirometry ; Surveys and Questionnaires

Background: Poor asthma control may adversely affect mental health. Our study investigates the correlation between inadequate asthma control, exhaled nitric oxide (FENO) levels, and anxiety and depression among pediatric asthma patients with COVID-19.
Methods: This prospective case-control study enrolled 520 asthmatic children (8-15 years), including 336 patients diagnosed with COVID-19 after rapid antigen testing at home and 184 age-matched asthmatic patients without COVID-19 infection. FENO and spirometry were performed 1 month after COVID-19 infection. Scores for Child Anxiety-Related Disorders (SCARED) and depression screen derived from Patient Health Questionnaire-9 (PHQ-9) to assess their mental health status. Childhood asthma control test (C-ACT), FENO levels, and spirometry were correlated with the SCARED and PHQ-9 questionnaires.
Results: SCARED subscales, including generalized anxiety disorder, social anxiety disorder, school avoidance, and depression scores from PHQ-9, exhibited a significant increase in asthmatic patients diagnosed with COVID-19 (p < .05). Among asthmatic children with SARS-CoV-2 infection, the poor asthma control group exhibited the highest SCARED and PHQ-9 measurements (p < .01). Multiple linear regression analysis indicated that reduced C-ACT scores and elevated FENO levels in asthmatic children with COVID-19 were significant risk factors for both anxiety and depression scores (p < .05). Lower C-ACT scales were associated with high scores of SCARED (r = -0.471) and PHQ-9 (r = -0.329) in asthmatic children (p < .001).
Conclusions: The current study emphasizes the need for healthcare professionals to closely monitor asthma control in asthmatic children to prevent heightened risks of depression and anxiety during the ongoing COVID-19 pandemic.
(© 2024 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

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Changhua Christian Hospital; Ministry of Science and Technology, Taiwan

Keywords: allergic asthma; anxiety; asthma control; depression; fractional exhaled nitric oxide

31C4KY9ESH (Nitric Oxide)

Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240614

20240614

10.1111/pai.14168

38873913