Detection of carbapenemase producing Acinetobacter baumannii ST19 from Georgia and Ukraine carrying bla OXA-23 , bla OXA-72 , and/or bla NDM-5 , December 2019 to June 2023.

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  • Additional Information
    • Source:
      Publisher: European Centre for Disease Prevention and Control (ECDC) Country of Publication: Sweden NLM ID: 100887452 Publication Model: Print Cited Medium: Internet ISSN: 1560-7917 (Electronic) Linking ISSN: 1025496X NLM ISO Abbreviation: Euro Surveill Subsets: MEDLINE
    • Publication Information:
      Publication: Stockholm, Sweden : European Centre for Disease Prevention and Control (ECDC)
      Original Publication: Saint-Maurice : Hôpital national de Saint-Maurice
    • Subject Terms:
      beta-Lactamases*/genetics ; Acinetobacter baumannii*/genetics ; Acinetobacter baumannii*/isolation & purification ; Acinetobacter baumannii*/drug effects ; Acinetobacter baumannii*/enzymology ; Acinetobacter Infections*/microbiology ; Acinetobacter Infections*/epidemiology ; Bacterial Proteins*/genetics ; Microbial Sensitivity Tests*; Humans ; Ukraine/epidemiology ; Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Phylogeny ; Drug Resistance, Multiple, Bacterial/genetics ; Georgia (Republic)/epidemiology ; Multilocus Sequence Typing
    • Abstract:
      In 2003-2023, amid 5,436 Acinetobacter baumannii isolates collected globally through the Multidrug-Resistant Organism Repository and Surveillance Network, 97 were ST19PAS, 34 of which carbapenem-resistant. Strains (n = 32) sampled after 2019 harboured either bla OXA-23 , bla OXA-72 , and/or bla NDM-5 . Phylogenetic analysis of the 97 isolates and 11 publicly available ST19 genomes revealed three sub-lineages of carbapenemase-producing isolates from mainly Ukraine and Georgia, including an epidemic clone carrying all three carbapenemase genes. Infection control and global surveillance of carbapenem-resistant A. baumannii remain important.
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    • Contributed Indexing:
      Keywords: A. baumannii; Acinetobacter baumannii; NDM; antimicrobial resistance; carbapenem resistance; microbial genomics; molecular epidemiology; nosocomial outbreak; surveillance
    • Accession Number:
      EC 3.5.2.6 (beta-Lactamases)
      EC 3.5.2.6 (carbapenemase)
      0 (Bacterial Proteins)
      0 (Anti-Bacterial Agents)
      0 (Carbapenems)
      EC 3.5.2.6 (OXA-72 carbapenemase, Acinetobacter baumannii)
      EC 3.5.2.- (beta-lactamase OXA-23)
    • Publication Date:
      Date Created: 20240614 Date Completed: 20240614 Latest Revision: 20240616
    • Publication Date:
      20240616
    • Accession Number:
      PMC11177571
    • Accession Number:
      10.2807/1560-7917.ES.2024.29.24.2400259
    • Accession Number:
      38873796