Irisin ameliorates UUO-induced renal interstitial fibrosis through TGF-β1/periostin/MMP-2 signaling pathway.

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  • Additional Information
    • Source:
      Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
    • Publication Information:
      Original Publication: San Francisco, CA : Public Library of Science
    • Subject Terms:
      Ureteral Obstruction*/complications ; Ureteral Obstruction*/pathology ; Ureteral Obstruction*/metabolism ; Ureteral Obstruction*/drug therapy ; Fibrosis* ; Fibronectins*/metabolism ; Matrix Metalloproteinase 2*/metabolism ; Matrix Metalloproteinase 2*/genetics ; Signal Transduction*/drug effects ; Transforming Growth Factor beta1*/metabolism ; Cell Adhesion Molecules*/metabolism ; Cell Adhesion Molecules*/genetics ; Epithelial-Mesenchymal Transition*/drug effects ; Kidney Diseases*/metabolism ; Kidney Diseases*/pathology ; Kidney Diseases*/etiology ; Kidney Diseases*/drug therapy; Animals ; Mice ; Male ; Humans ; Kidney/pathology ; Kidney/metabolism ; Kidney/drug effects ; Mice, Inbred C57BL ; Cell Line ; Disease Models, Animal ; Periostin
    • Abstract:
      Renal fibrosis is the most common pathway in progressive kidney diseases. The unilateral ureteral obstruction (UUO) model is used to induce progressive renal fibrosis. We evaluated the effects of irisin on renal interstitial fibrosis in UUO mice. The GSE121190, GSE36496, GSE42303, and GSE96101 datasets were downloaded from the Gene Expression Omnibus (GEO) database. In total, 656 differentially expressed genes (DEGs) were identified in normal and UUO mouse renal samples. Periostin and matrix metalloproteinase-2 (MMP-2) were selected to evaluate the effect of irisin on renal fibrosis in UUO mice. In UUO mice, irisin ameliorated renal function, decreased the expression of periostin and MMP-2, and attenuated epithelial-mesenchymal transition and extracellular matrix deposition in renal tissues. In HK-2 cells, irisin treatment markedly attenuated TGF-β1-induced expression of periostin and MMP-2. Irisin treatment also inhibited TGF-β1-induced epithelial-mesenchymal transition, extracellular matrix formation, and inflammatory responses. These protective effects of irisin were abolished by the overexpression of periostin and MMP-2. In summary, irisin treatment can improve UUO-induced renal interstitial fibrosis through the TGF-β1/periostin/MMP-2 signaling pathway, suggesting that irisin may be used for the treatment of renal interstitial fibrosis.
      Competing Interests: The authors declare that there is no conflict of interests.
      (Copyright: © 2024 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
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    • Accession Number:
      0 (Fibronectins)
      EC 3.4.24.24 (Matrix Metalloproteinase 2)
      0 (Transforming Growth Factor beta1)
      0 (Cell Adhesion Molecules)
      0 (Postn protein, mouse)
      0 (FNDC5 protein, mouse)
      0 (Periostin)
    • Publication Date:
      Date Created: 20240613 Date Completed: 20240613 Latest Revision: 20240615
    • Publication Date:
      20240615
    • Accession Number:
      PMC11175535
    • Accession Number:
      10.1371/journal.pone.0299389
    • Accession Number:
      38870184