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Real-world data on patients with early breast cancer who were prescribed abemaciclib adjuvant therapy in Japan.
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- Author(s): Shimoi T;Shimoi T; Pathadka S; Pathadka S; Sekine N; Sekine N; Cai Z; Cai Z; Tanizawa Y; Tanizawa Y; Kawaguchi T; Kawaguchi T; Saji S; Saji S; Yamashita T; Yamashita T
- Source:
Future oncology (London, England) [Future Oncol] 2024 May 29, pp. 1-10. Date of Electronic Publication: 2024 May 29.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Publication Information: Ahead of Print
- Source: Publisher: Future Medicine Ltd Country of Publication: England NLM ID: 101256629 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-8301 (Electronic) Linking ISSN: 14796694 NLM ISO Abbreviation: Future Oncol Subsets: MEDLINE
- Publication Information: Original Publication: London : Future Medicine Ltd., c2005-
- Abstract: Aim: To understand the real-world use of abemaciclib in Japanese patients with early breast cancer (EBC). Methods: This retrospective observational study was conducted using a Japanese administrative claims database in patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative EBC who received abemaciclib adjuvant therapy from December 2021-March 2023. Patient characteristics and treatment patterns were summarized. Results: Among 374 patients, 38.2, 51.6 and 63.4% patients received neoadjuvant chemotherapy, adjuvant chemotherapy and radiotherapy, respectively; 13.1% were chemotherapy naive. Tamoxifen (37.7%), letrozole (35.6%), anastrozole (24.3%) were the commonly prescribed concomitant adjuvant endocrine therapies. Abemaciclib dose reductions were observed in 42.0% patients. Conclusion: Use of abemaciclib for treatment of high-risk EBC was described, which could help inform patient selection and treatment patterns.
- Contributed Indexing: Keywords: abemaciclib; administrative database; early breast cancer; real-world evidence
Local Abstract: [plain-language-summary] Abemaciclib (150 mg twice daily) is prescribed with hormonal therapy for the treatment of early breast cancer (EBC) with high risk of recurrence. We used a big database from Japan that has anonymized information about 44 million patients from 480 hospitals. We aim to describe the characteristics of patients with EBC who receive abemaciclib and their treatment patterns in Japan.We included 374 patients with EBC who had breast cancer surgery and were prescribed abemaciclib with hormonal therapy between December 2021 and March 2023. The median age of patients is 54 years, almost all (99.2%) are female. The most commonly prescribed hormonal therapy with abemaciclib is tamoxifen (37.7%), letrozole (35.6%) and anastrozole (24.3%).Of the 374 patients who were prescribed abemaciclib, 38.2% patients received chemotherapy before surgery, 51.6% received chemotherapy after surgery and 63.4% received radiation therapy after surgery; whereas, 13.1% received no perioperative chemotherapy before abemaciclib therapy. Around 42% of patients reduced their dose from starting dose of abemaciclib. Higher proportion of older patients and patients with low body weight, had dose reduction. Majority of the patients are prescribed either an antidiarrheal agent or probiotic within a day of starting abemaciclib.This is the first study describing patient characteristics and treatment patterns of Japanese patients who are prescribed abemaciclib in the clinical practice. The results will help understand who can benefit from abemaciclib, and to choose the most appropriate patients to receive abemaciclib for the treatment of EBC. - Publication Date: Date Created: 20240611 Latest Revision: 20240611
- Publication Date: 20240611
- Accession Number: 10.1080/14796694.2024.2346464
- Accession Number: 38861285
- Publication Information:
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