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The synergy of recombinant NSP4 and VP4 from porcine rotavirus elicited a strong mucosal response.
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- Author(s): Li S;Li S;Li S; Tang X; Tang X; Zhou J; Zhou J; Zhou J; Zhou J; Bian X; Bian X; Wang J; Wang J; Gu L; Gu L; Zhu X; Zhu X; Zhu X; Zhu X; Tao R; Tao R; Sun M; Sun M; Sun M; Sun M; Zhang X; Zhang X; Zhang X; Zhang X; Li B; Li B; Li B; Li B; Li B
- Source:
Virology [Virology] 2024 Sep; Vol. 597, pp. 110130. Date of Electronic Publication: 2024 Jun 04.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Academic Press Country of Publication: United States NLM ID: 0110674 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0341 (Electronic) Linking ISSN: 00426822 NLM ISO Abbreviation: Virology Subsets: MEDLINE
- Publication Information: Original Publication: New York, Academic Press.
- Subject Terms: Viral Nonstructural Proteins*/genetics ; Viral Nonstructural Proteins*/immunology ; Rotavirus*/immunology ; Rotavirus*/genetics ; Capsid Proteins*/genetics ; Capsid Proteins*/immunology ; Immunity, Mucosal* ; Rotavirus Infections*/virology ; Rotavirus Infections*/immunology ; Rotavirus Infections*/veterinary ; Rotavirus Infections*/prevention & control ; Antibodies, Viral*/immunology; Animals ; Swine ; Rotavirus Vaccines/immunology ; Rotavirus Vaccines/administration & dosage ; Rotavirus Vaccines/genetics ; Toxins, Biological/genetics ; Toxins, Biological/immunology ; Glycoproteins/genetics ; Glycoproteins/immunology ; Recombinant Proteins/immunology ; Recombinant Proteins/genetics ; Immunoglobulin A/immunology ; Swine Diseases/virology ; Swine Diseases/immunology ; Adjuvants, Immunologic/administration & dosage ; Feces/virology ; Immunoglobulin G/immunology ; Antigens, Viral/immunology ; Antigens, Viral/genetics
- Abstract: Porcine rotavirus (PoRV) is one of the main pathogens causing diarrhea in piglets, and multiple genotypes coexist. However, an effective vaccine is currently lacking. Here, the potential adjuvant of nonstructural protein 4 (NSP4) and highly immunogenic structural protein VP4 prompted us to construct recombinant NSP4
86-175aa (NSP4*) and VP426-476aa (VP4*) proteins, combine them as immunogens to evaluate their efficacy. Results indicated that NSP4* enhanced systemic and local mucosal responses induced by VP4*. The VP4*-IgG, VP4*-IgA in feces and IgA-secreting cells in intestines induced by the co-immunization were significantly higher than those induced by VP4* alone. Co-immunization of NSP4* and VP4* also induced strong cellular immunity with significantly increased IFN-λ than the single VP4*. Summarily, the NSP4* as a synergistical antigen exerted limited effects on the PoRV NAbs elevation, but conferred strong VP4*-specific mucosal and cellular efficacy, which lays the foundation for the development of a more effective porcine rotavirus subunit vaccine.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.) - Contributed Indexing: Keywords: Mucosal immunity; NSP4; Porcine; Rotavirus; VP4
- Accession Number: 0 (Viral Nonstructural Proteins)
0 (Capsid Proteins)
0 (NS28 protein, rotavirus)
0 (VP4 protein, Rotavirus)
0 (Antibodies, Viral)
0 (Rotavirus Vaccines)
0 (Toxins, Biological)
0 (Glycoproteins)
0 (Recombinant Proteins)
0 (Immunoglobulin A)
0 (Adjuvants, Immunologic)
0 (Immunoglobulin G)
0 (Antigens, Viral) - Publication Date: Date Created: 20240608 Date Completed: 20240718 Latest Revision: 20240819
- Publication Date: 20240819
- Accession Number: 10.1016/j.virol.2024.110130
- Accession Number: 38850894
- Source:
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