Fronto-thalamic networks and the left ventral thalamic nuclei play a key role in aphasia after thalamic stroke.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: Electronic Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: MEDLINE
    • Publication Information:
      Original Publication: London, United Kingdom : Nature Publishing Group UK, [2018]-
    • Subject Terms:
      Ventral Thalamic Nuclei*/physiopathology ; Ventral Thalamic Nuclei*/diagnostic imaging ; Aphasia*/physiopathology ; Aphasia*/etiology ; Aphasia*/diagnostic imaging ; Magnetic Resonance Imaging* ; Stroke*/complications ; Stroke*/physiopathology ; Thalamus*/physiopathology ; Thalamus*/diagnostic imaging; Humans ; Male ; Middle Aged ; Female ; Aged ; Adult ; Connectome ; Frontal Lobe/physiopathology ; Frontal Lobe/diagnostic imaging ; Nerve Net/physiopathology ; Nerve Net/diagnostic imaging ; Neural Pathways/physiopathology
    • Abstract:
      Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates of thalamic aphasia remain incompletely understood. Using lesion symptom mapping, we demonstrate that lesions in the left ventrolateral and ventral anterior thalamic nucleus are most strongly associated with aphasia in general and with impaired semantic and phonemic fluency and complex comprehension in particular. Lesion network mapping (using a normative connectome based on fMRI data from 1000 healthy individuals) reveals a Thalamic aphasia network encompassing widespread left-hemispheric cerebral connections, with Broca's area showing the strongest associations, followed by the superior and middle frontal gyri, precentral and paracingulate gyri, and globus pallidus. Our results imply the critical involvement of the left ventrolateral and left ventral anterior thalamic nuclei in engaging left frontal cortical areas, especially Broca's area, during language processing.
      (© 2024. The Author(s).)
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    • Publication Date:
      Date Created: 20240607 Date Completed: 20240607 Latest Revision: 20241217
    • Publication Date:
      20241217
    • Accession Number:
      PMC11161613
    • Accession Number:
      10.1038/s42003-024-06399-9
    • Accession Number:
      38849518