Propranolol attenuates the establishment of conditioned context aversions: differential effects compared to MK-801 in an animal model of anticipatory nausea and vomiting.

Publisher: Lippincott Williams and Wilkins Country of Publication: England NLM ID: 9013016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5849 (Electronic) Linking ISSN: 09558810 NLM ISO Abbreviation: Behav Pharmacol Subsets: MEDLINE

Publication: London : Lippincott Williams and Wilkins
Original Publication: London : Clinical Neuroscience Publishers,

Propranolol*/pharmacology ; Dizocilpine Maleate*/pharmacology ; Adrenergic beta-Antagonists*/pharmacology ; Disease Models, Animal* ; Conditioning, Classical*/drug effects; Animals ; Male ; Mice ; Nausea/drug therapy ; Nausea/chemically induced ; Avoidance Learning/drug effects ; Lithium Chloride/pharmacology ; Vomiting, Anticipatory ; Excitatory Amino Acid Antagonists/pharmacology ; Dose-Response Relationship, Drug

Cancer patients often experience anticipatory nausea and vomiting (ANV) due to Pavlovian conditioning. Both N-methyl-D-aspartate and beta-adrenergic receptors are known to mediate memory formation, but their role in the development of ANV remains unclear. This study used a conditioned context aversion (CCA) paradigm, an animal model for ANV, to assess whether administration of the beta-adrenergic receptor antagonist propranolol or the N-methyl-D-aspartate receptor antagonist MK-801 immediately after CCA training has an effect on the later expression of CCA in CD1 male mice. In experiment 1, three groups were injected with lithium chloride (LiCl) to induce aversion in a novel context, resulting in CCA. A control group was injected with sodium chloride (NaCl). Following conditioning, two of the LiCl-treated groups received different doses of MK-801 (0.05 or 0.2 mg/kg), while the remaining LiCl-treated and NaCl-treated groups received a second NaCl injection. In experiment 2, two groups were injected with LiCl, and one group was injected with NaCl. After conditioning, one of the LiCl-treated groups received a propranolol injection (10 mg/kg). The remaining LiCl-treated and NaCl-treated groups received NaCl injections. Water consumption was measured in all groups 72 h later within the conditioning context. Postconditioning administration of propranolol, but not MK-801, attenuated CCA, as revealed by similar levels of water consumption in animals that received LiCl and propranolol relative to NaCl-treated animals. These findings suggest that beta-adrenergic receptor activation is crucial for the development of CCA. Therefore, propranolol may represent a novel therapeutic approach for cancer patients at high risk of ANV.
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9Y8NXQ24VQ (Propranolol)
6LR8C1B66Q (Dizocilpine Maleate)
0 (Adrenergic beta-Antagonists)
G4962QA067 (Lithium Chloride)
0 (Excitatory Amino Acid Antagonists)

Date Created: 20240607 Date Completed: 20240705 Latest Revision: 20240705

20240705

10.1097/FBP.0000000000000779

38847463